Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Immunology. 2023 Feb;168(2):199-202. doi: 10.1111/imm.13456. Epub 2022 Mar 1.
Prostate cancer is still a public health priority in men and the impact of this disease will be more pronounced with the ageing of the world's population. Clinical heterogeneity of prostate cancer is reflected in spatial and clonal genomic diversity. Accumulating evidence demonstrates that the malignant behaviour of cancer is not only attributed to cancer cells but also fundamentally affected by stromal activity and controlled by various mechanisms of the tumour microenvironment. Data on prostate cancer in this study was derived from seven GEO datasets and the TCGA database. We analyzed the tumour microenvironment of prostate cancer in terms of clinical process, T stage and Gleason score using EPIC and xCell algorithms. We also analyzed the common immune checkpoints. In this study, we confirmed remarkable tumour tissue remodelling in the development of prostate cancer and further demonstrated the importance of cancer-related fibroblasts in the biochemical recurrence and metastasis for patients with prostate cancer undergoing radical radiotherapy or prostatectomy. In addition, we found that NRP1, CD200, TNFSF18 and CD80 might be the potential targets for prostate cancer.
前列腺癌仍然是男性健康的一个公共卫生重点，随着世界人口的老龄化，这种疾病的影响将更加明显。前列腺癌的临床异质性反映在空间和克隆基因组多样性上。越来越多的证据表明，癌症的恶性行为不仅归因于癌细胞，而且还受到基质活性的根本影响，并受肿瘤微环境的各种机制控制。本研究中前列腺癌的数据来自 7 个 GEO 数据集和 TCGA 数据库。我们使用 EPIC 和 xCell 算法，根据临床过程、T 分期和 Gleason 评分分析前列腺癌的肿瘤微环境。我们还分析了常见的免疫检查点。在这项研究中，我们证实了在前列腺癌发展过程中显著的肿瘤组织重塑，并进一步证明了在接受根治性放疗或前列腺切除术的前列腺癌患者中，与癌症相关的成纤维细胞在生化复发和转移中的重要性。此外，我们发现 NRP1、CD200、TNFSF18 和 CD80 可能是前列腺癌的潜在靶点。
