Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur 784028, Assam, India; National Centre for Cell Science, Pune 411007, Maharashtra, India.
Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Int J Biol Macromol. 2021 Dec 1;192:1040-1057. doi: 10.1016/j.ijbiomac.2021.10.015. Epub 2021 Oct 14.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent responsible for the Coronavirus Disease-2019 (COVID-19) pandemic, has infected over 185 million individuals across 200 countries since December 2019 resulting in 4.0 million deaths. While COVID-19 is primarily associated with respiratory illnesses, an increasing number of clinical reports indicate that severely ill patients often develop thrombotic complications that are associated with increased mortality. As a consequence, treatment strategies that target COVID-associated thrombosis are of utmost clinical importance. An array of pharmacologically active compounds from natural products exhibit effects on blood coagulation pathways, and have generated interest for their potential therapeutic applications towards thrombotic diseases. In particular, a number of snake venom compounds exhibit high specificity on different blood coagulation factors and represent excellent tools that could be utilized to treat thrombosis. The aim of this review is to provide a brief summary of the current understanding of COVID-19 associated thrombosis, and highlight several snake venom compounds that could be utilized as antithrombotic agents to target this disease.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是导致 2019 年冠状病毒病（COVID-19）大流行的病原体，自 2019 年 12 月以来，已在 200 个国家感染了超过 1.85 亿人，导致 400 万人死亡。虽然 COVID-19 主要与呼吸道疾病有关，但越来越多的临床报告表明，重症患者经常出现血栓并发症，这与死亡率增加有关。因此，针对 COVID 相关血栓形成的治疗策略具有非常重要的临床意义。天然产物中的一系列具有药理活性的化合物对凝血途径有影响，并因其在血栓性疾病治疗方面的潜在应用而引起关注。特别是，一些蛇毒化合物对不同的凝血因子具有高度特异性，是可用于治疗血栓形成的极好工具。本文综述的目的是简要概述 COVID-19 相关血栓形成的当前认识，并强调几种可作为抗血栓药物用于靶向治疗该疾病的蛇毒化合物。
