Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, China.
College of Pharmacy, Dali University, Dali, People's Republic of China.
Nat Prod Res. 2023 Jul;37(13):2243-2247. doi: 10.1080/14786419.2022.2037589. Epub 2022 Feb 11.
A new antifungal butenolide irperide () along with five known compounds were isolated from the co-culture of endophyte and pathogenic . The structure of , including the absolute configuration, was elucidated by analysis of NMR, HR-ESI-MS data and ECD spectra. Compounds , and exhibited significant antifungal activity against , with MIC values of 1, 2 and 1 μg/mL, respectively.
从内生真菌 和病原菌的共培养物中分离得到了一种新的抗真菌丁烯内酯化合物 irperide () 以及五种已知化合物。通过分析 NMR、HR-ESI-MS 数据和 ECD 光谱，阐明了 的结构，包括绝对构型。化合物 、 和 对 表现出显著的抗真菌活性，MIC 值分别为 1、2 和 1μg/mL。
