Yin Hai-Yue, Yang Xue-Qiong, Wang Dai-Li, Zhao Tong-De, Wang Cui-Fang, Yang Ya-Bin, Ding Zhong-Tao
Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of China.
Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of China.
Fitoterapia. 2021 Jan;148:104781. doi: 10.1016/j.fitote.2020.104781. Epub 2020 Nov 28.
Five new tremulane sesquiterpenoids were isolated from co-culture of endophyte Irpex lacteus, phytopathogen Nigrospora oryzae, and entomopathogen Beauveria bassiana. All compounds showed obvious antifeedant activities against silkworm with inhibition percentages of 73-99%, at concentrations of 50 μg/cm. Compound 11 indicated notable antifeedant activity with inhibition percentage of 93% at concentration of 6.25 μg/cm among them. Compounds 2, 3, 4, 8, 9, 15 and 16 indicated anti-fungal activities against I. lacteus with MIC values ≤8 μg/mL, compounds 11, 12, 16-18 showed significant anti-fungal activity against N. oryzae with MICs ≤ 4 μg/mL, and compounds 2, 5, 12 and 18 indicated significant anti-fungal activity against B. bassiana with MICs ≤ 8 μg/mL. In addition, the I. lacteus should unite B. bassiana to inhibit the production of phytotoxins from N. oryzae in the ternary culture.
从内生真菌白纹黄多孔菌、植物病原菌稻黑孢和昆虫病原菌球孢白僵菌的共培养物中分离出5种新的倍半萜类震颤烷型化合物。所有化合物在浓度为50μg/cm时对家蚕均表现出明显的拒食活性，抑制率为73%-99%。其中化合物11在浓度为6.25μg/cm时表现出显著的拒食活性，抑制率为93%。化合物2、3、4、8、9、15和16对白纹黄多孔菌表现出抗真菌活性，最低抑菌浓度（MIC）值≤8μg/mL；化合物11、12、16-18对稻黑孢表现出显著的抗真菌活性，MIC≤4μg/mL；化合物2、5、12和18对球孢白僵菌表现出显著的抗真菌活性，MIC≤8μg/mL。此外，在三元培养中，白纹黄多孔菌应与球孢白僵菌联合抑制稻黑孢产生植物毒素。
