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轻度至中度原发性高血压黑人患者的钾补充治疗

Potassium supplementation in blacks with mild to moderate essential hypertension.

作者信息

Matlou S M, Isles C G, Higgs A, Milne F J, Murray G D, Schultz E, Starke I F

出版信息

J Hypertens. 1986 Feb;4(1):61-4. doi: 10.1097/00004872-198602000-00010.

DOI:10.1097/00004872-198602000-00010
PMID:3514747
Abstract

Potassium chloride (KCl) salt (65 mmol) daily reduced BP from 153/104 to 146/101 mmHg in 32 hypertensive black females during a 6-week placebo controlled crossover study. The fall in BP was independent of the order of randomization and was significant for systolic (SBP; P less than 0.01) and diastolic (DBP; P less than 0.05) pressure after 4 weeks. Analysis of the 95% confidence intervals in this and in five other studies, two of which were reported as showing no beneficial effect, suggests that potassium supplementation does lower BP, but that the change is small and within the confidence levels of all six trials. Thus, apparent discrepancies in the literature are not genuine statistically.

摘要

在一项为期6周的安慰剂对照交叉研究中,32名高血压黑人女性每日服用65毫摩尔氯化钾盐,血压从153/104毫米汞柱降至146/101毫米汞柱。血压下降与随机分组顺序无关,4周后收缩压(SBP;P<0.01)和舒张压(DBP;P<0.05)均显著下降。对本研究以及其他五项研究的95%置信区间进行分析(其中两项研究报告显示无有益效果)表明,补充钾确实能降低血压,但变化很小,且在所有六项试验的置信水平范围内。因此,文献中明显的差异在统计学上并非真实存在。

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