使用定量分析比较扑米酮、普萘洛尔和安慰剂治疗特发性震颤的效果。
A comparison of primidone, propranolol, and placebo in essential tremor, using quantitative analysis.
作者信息
Gorman W P, Cooper R, Pocock P, Campbell M J
出版信息
J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):64-8. doi: 10.1136/jnnp.49.1.64.
Abstract
The effects of placebo, propranolol and primidone were compared in 14 patients with essential tremor in a double blind, randomised, crossover study. Objective measures of tremor were obtained using an accelerometer with subsequent spectral analysis. Both propranolol (p less than 0.01) and primidone (p less than 0.01) gave significant improvement in tremor, but there was no significant difference in improvement between these drugs. Patients with higher dominant frequencies of tremor tended to respond to both drugs, while those with lower frequencies improved on one or other. There was no differential effect between the drugs with the frequency of tremor.
摘要
在一项双盲、随机、交叉研究中，对14例特发性震颤患者比较了安慰剂、普萘洛尔和扑米酮的效果。使用加速度计及随后的频谱分析获得震颤的客观测量值。普萘洛尔（p<0.01）和扑米酮（p<0.01）均使震颤有显著改善，但这两种药物在改善效果上无显著差异。震颤优势频率较高的患者倾向于对两种药物均有反应，而频率较低的患者则对其中一种药物有改善。两种药物在震颤频率方面无差异效应。
相似文献
1
A comparison of primidone, propranolol, and placebo in essential tremor, using quantitative analysis.使用定量分析比较扑米酮、普萘洛尔和安慰剂治疗特发性震颤的效果。
J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):64-8. doi: 10.1136/jnnp.49.1.64.
2
Adjuvant therapy of parkinsonian tremor.帕金森震颤的辅助治疗。
Arch Neurol. 1987 Sep;44(9):921-3. doi: 10.1001/archneur.1987.00520210023013.
3
Primidone and propranolol in essential tremor: a study based on quantitative tremor recording and plasma anticonvulsant levels.扑米酮与普萘洛尔治疗特发性震颤：一项基于震颤定量记录及血浆抗惊厥药水平的研究
Acta Neurol Scand. 1987 May;75(5):332-40. doi: 10.1111/j.1600-0404.1987.tb05455.x.
4
Primidone in essential tremor of the hands and head: a double blind controlled clinical study.扑米酮治疗手部和头部特发性震颤：一项双盲对照临床研究。
J Neurol Neurosurg Psychiatry. 1985 Sep;48(9):911-5. doi: 10.1136/jnnp.48.9.911.
5
Acute and chronic effects of propranolol and primidone in essential tremor.普萘洛尔和扑米酮对特发性震颤的急慢性影响。
Neurology. 1989 Dec;39(12):1587-8. doi: 10.1212/wnl.39.12.1587.
6
Double-blind comparison of primidone and phenobarbital in essential tremor.扑米酮与苯巴比妥治疗特发性震颤的双盲对照研究
Neurology. 1988 May;38(5):808-10. doi: 10.1212/wnl.38.5.808.
7
Double-blind controlled study of primidone in essential tremor: preliminary results.扑米酮治疗特发性震颤的双盲对照研究：初步结果。
Br Med J (Clin Res Ed). 1982;285(6342):608. doi: 10.1136/bmj.285.6342.608.
8
Efficacy of primidone in essential tremor.扑米酮治疗特发性震颤的疗效。
Neurology. 1986 Jan;36(1):121-4. doi: 10.1212/wnl.36.1.121.
9
Phenobarbital and propranolol in essential tremor: a double-blind controlled clinical trial.苯巴比妥与普萘洛尔治疗特发性震颤：一项双盲对照临床试验。
Neurology. 1983 Mar;33(3):296-300. doi: 10.1212/wnl.33.3.296.
10
Disability in essential tremor: effect of treatment.特发性震颤中的残疾：治疗效果
Neurology. 1986 Jul;36(7):1001-4. doi: 10.1212/wnl.36.7.1001.
引用本文的文献
1
Primidone Intolerance in Essential tremor: Is it More than Just Age?扑米酮不耐受在特发性震颤中的表现：仅仅是年龄因素吗？
Tremor Other Hyperkinet Mov (N Y). 2021 Dec 31;11:57. doi: 10.5334/tohm.672. eCollection 2021.
2
GABA, Glutamate, and NAA Levels in the Deep Cerebellar Nuclei of Essential Tremor Patients.特发性震颤患者小脑深部核团中γ-氨基丁酸、谷氨酸和N-乙酰天门冬氨酸水平
Front Neurol. 2021 May 6;12:664735. doi: 10.3389/fneur.2021.664735. eCollection 2021.
3
Anti-Tremor Action of Subtype Selective Positive Allosteric Modulators of GABA Receptors in a Rat Model of Essential Tremors.GABA 受体亚型选择性正变构调节剂在特发性震颤大鼠模型中的抗震颤作用。
Cerebellum. 2020 Apr;19(2):265-274. doi: 10.1007/s12311-020-01106-w.
4
Current and Future Neuropharmacological Options for the Treatment of Essential Tremor.治疗原发性震颤的当前和未来神经药理学选择。
Curr Neuropharmacol. 2020;18(6):518-537. doi: 10.2174/1570159X18666200124145743.
5
Differential effects of propranolol on head and upper limb tremor in patients with essential tremor and dystonia.普萘洛尔对特发性震颤和肌张力障碍患者头部和上肢震颤的影响差异。
J Neurol. 2018 Nov;265(11):2695-2703. doi: 10.1007/s00415-018-9052-z. Epub 2018 Sep 12.
6
Objective predictors of 'early tolerance' to ventral intermediate nucleus of thalamus deep brain stimulation in essential tremor patients.原发性震颤患者丘脑腹中间核深部脑刺激“早期耐受”的客观预测指标。
Clin Neurophysiol. 2018 Aug;129(8):1628-1633. doi: 10.1016/j.clinph.2018.05.012. Epub 2018 Jun 5.
7
Transducer-based evaluation of tremor.基于换能器的震颤评估。
Mov Disord. 2016 Sep;31(9):1327-36. doi: 10.1002/mds.26671. Epub 2016 Jun 6.
8
Arm movement speed assessment via a Kinect camera: a preliminary study in healthy subjects.通过Kinect摄像头评估手臂运动速度：在健康受试者中的初步研究。
Biomed Eng Online. 2014 Jun 27;13:88. doi: 10.1186/1475-925X-13-88.
9
Pharmacotherapy of essential tremor.特发性震颤的药物治疗
J Cent Nerv Syst Dis. 2013 Dec 22;5:43-55. doi: 10.4137/JCNSD.S6561.
10
Measures of fine motor skills in people with tremor disorders: appraisal and interpretation.震颤障碍患者精细运动技能的测量：评估与解读。
Front Neurol. 2013 May 10;4:50. doi: 10.3389/fneur.2013.00050. eCollection 2013.
本文引用的文献
1
Essential tremor: response to primidone.特发性震颤：对扑米酮的反应
J Neurol Neurosurg Psychiatry. 1981 Jul;44(7):650. doi: 10.1136/jnnp.44.7.650.
2
Double-blind controlled study of primidone in essential tremor: preliminary results.扑米酮治疗特发性震颤的双盲对照研究：初步结果。
Br Med J (Clin Res Ed). 1982;285(6342):608. doi: 10.1136/bmj.285.6342.608.
3
Primidone in essential tremor.
Br Med J (Clin Res Ed). 1982 Nov 13;285(6352):1424. doi: 10.1136/bmj.285.6352.1424.
4
Benign familial tremor treated with primidone.用扑米酮治疗良性家族性震颤。
Br Med J (Clin Res Ed). 1981 Jan 17;282(6259):178-80. doi: 10.1136/bmj.282.6259.178.
5
Essential tremor in Rochester, Minnesota: a 45-year study.明尼苏达州罗切斯特市的特发性震颤：一项为期45年的研究。
J Neurol Neurosurg Psychiatry. 1984 May;47(5):466-70. doi: 10.1136/jnnp.47.5.466.
6
Beta-adrenoreceptor mechanisms in essential tremor: a comparative single dose study of the effect of a non-selective and a beta-2 selective adrenoreceptor antagonist.原发性震颤中的β-肾上腺素能受体机制：非选择性和β2选择性肾上腺素能受体拮抗剂作用的单剂量比较研究
J Neurol Neurosurg Psychiatry. 1984 Sep;47(9):976-82. doi: 10.1136/jnnp.47.9.976.
7
Essential tremor.
Clin Neuropharmacol. 1983;6(3):185-206. doi: 10.1097/00002826-198309000-00002.
8
The response of essential tremor to propranolol: evaluation of clinical variables governing its efficacy on prolonged administration.特发性震颤对普萘洛尔的反应：对长期给药时影响其疗效的临床变量的评估。
J Neurol Neurosurg Psychiatry. 1983 May;46(5):393-8. doi: 10.1136/jnnp.46.5.393.
9
The control of essential tremor by propranolol.普萘洛尔对特发性震颤的控制
Trans Am Neurol Assoc. 1971;96:66-8.
10
Effect of the beta adrenergic blocking agent propranolol on essential tremor.β-肾上腺素能阻滞剂普萘洛尔对特发性震颤的作用。
J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):618-24. doi: 10.1136/jnnp.36.4.618.
Zotero 插件