Gorman W P, Cooper R, Pocock P, Campbell M J
J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):64-8. doi: 10.1136/jnnp.49.1.64.
The effects of placebo, propranolol and primidone were compared in 14 patients with essential tremor in a double blind, randomised, crossover study. Objective measures of tremor were obtained using an accelerometer with subsequent spectral analysis. Both propranolol (p less than 0.01) and primidone (p less than 0.01) gave significant improvement in tremor, but there was no significant difference in improvement between these drugs. Patients with higher dominant frequencies of tremor tended to respond to both drugs, while those with lower frequencies improved on one or other. There was no differential effect between the drugs with the frequency of tremor.
在一项双盲、随机、交叉研究中，对14例特发性震颤患者比较了安慰剂、普萘洛尔和扑米酮的效果。使用加速度计及随后的频谱分析获得震颤的客观测量值。普萘洛尔（p<0.01）和扑米酮（p<0.01）均使震颤有显著改善，但这两种药物在改善效果上无显著差异。震颤优势频率较高的患者倾向于对两种药物均有反应，而频率较低的患者则对其中一种药物有改善。两种药物在震颤频率方面无差异效应。
