School of Family and Consumer Sciences, Texas State University, San Marcos, Texas, USA.
Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa, USA.
Nutr Rev. 2022 Jul 7;80(8):1919-1926. doi: 10.1093/nutrit/nuac007.
Obesity is characterized by chronic low-grade inflammation that could lead to other health complications, such as cardiovascular disease, diabetes, and various forms of cancer. Emerging evidence has shown that taste perception is altered during the development of obesity. Moreover, suppression of taste receptor or taste signaling molecules potentiate the inflammatory response, and the progression of inflammation attenuates the expression of taste receptors in vivo. Together, these findings suggest a possible interplay between taste signaling and inflammation. This review summarizes the interactions between type 1 (T1Rs) and type 2 taste receptors (T2Rs) and inflammation, as well as the impact of obesity on T1R- and T2R-mediated signaling. Furthermore, we evaluate the possible role that taste receptors play in regulating the inflammatory response during obesity as a therapeutic target to prevent the progression of comorbidities associated with obesity.
肥胖的特征是慢性低度炎症，可能导致其他健康并发症，如心血管疾病、糖尿病和各种形式的癌症。新出现的证据表明，在肥胖的发展过程中，味觉感知会发生变化。此外，味觉受体或味觉信号分子的抑制会增强炎症反应，而炎症的进展会减弱体内味觉受体的表达。总之，这些发现表明味觉信号和炎症之间可能存在相互作用。本综述总结了 1 型（T1Rs）和 2 型味觉受体（T2Rs）与炎症之间的相互作用，以及肥胖对 T1R 和 T2R 介导的信号转导的影响。此外，我们评估了味觉受体在肥胖期间调节炎症反应中的可能作用，作为预防与肥胖相关的合并症进展的治疗靶点。
