Department of Medical Physics, Anna University, Tamil Nadu, India.
Department of Medical Physics, Anna University, Tamil Nadu, India.
Chemosphere. 2022 Jun;296:133918. doi: 10.1016/j.chemosphere.2022.133918. Epub 2022 Feb 9.
Herein, we propose a facile electrochemical sensing platform for urea detection using pencil graphite electrode modified nanocomposites of CuO/ZnO and FeO/ZnO. The detection of urea is essential to monitor for identifying its pollution in the water, at the soil surface and in diagnosing urea cycle disorder related diseases. Therefore, an effective, accurate, cost-effective method of diagnosis is urgently needed. Nanostructured metal oxides have the potential ability to detect molecules even at trace level and to explore this, the present work is formulated with Cu and Fe based ZnO nanocomposites for enhancing the sensing performance towards electrochemical sensing of urea. The sensing responses were confirmed from the increase in oxidation current with respect to the concentration of urea. The results show that FeO/ZnO coated graphite electrode has a higher response against urea compared to ZnO and CuO/ZnO. The cyclic voltammetry studies also validate urea sensing of Fe-ZnO in the linear range of 0.8 μg/mL to 4 μg/mL, with the detection limit of 2.5 μg/mL. This suggests that the cost-effective pencil graphite electrode modified FeO/ZnO can be utilized as a promising analytical tool for urea sensing.
在此，我们提出了一种使用铅笔石墨电极修饰的氧化铜/氧化锌和氧化铁/氧化锌纳米复合材料的简便电化学尿素检测传感平台。尿素的检测对于监测其在水中、土壤表面的污染以及诊断与尿素循环障碍相关的疾病至关重要。因此，迫切需要一种有效、准确、具有成本效益的诊断方法。纳米结构金属氧化物具有在痕量水平下检测分子的潜在能力，为了探索这一点，本工作采用基于 Cu 和 Fe 的 ZnO 纳米复合材料来提高对尿素电化学传感的传感性能。通过相对于尿素浓度的氧化电流增加来确认传感响应。结果表明，与 ZnO 和 CuO/ZnO 相比，氧化铁/氧化锌涂覆的石墨电极对尿素具有更高的响应。循环伏安法研究还验证了 Fe-ZnO 在 0.8μg/mL 至 4μg/mL 的线性范围内对尿素的传感，检测限为 2.5μg/mL。这表明，具有成本效益的铅笔石墨电极修饰的 FeO/ZnO 可以用作尿素传感的有前途的分析工具。
