Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, PR China.
Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA; Rutgers University, School of Public Health, Department of Biostatistics and Epidemiology, New Brunswick, NJ, USA.
Osteoarthritis Cartilage. 2022 May;30(5):697-701. doi: 10.1016/j.joca.2022.01.011. Epub 2022 Feb 9.
To examine the association of alcohol consumption with risk of incident knee osteoarthritis (OA) in a large prospective cohort study.
In the Osteoarthritis Initiative, 2,846 participants aged 45-79 years and free from radiographic knee OA in at least one knee at baseline were followed up to 96 months. Information on baseline alcohol consumption was obtained from the Block Brief Food Frequency Questionnaire. Incident cases of radiographic knee OA (ROA) were defined as Kellgren-Lawrence grade changing from zero or one to ≥ two during the follow-up time. Incident symptomatic OA (SxOA) was defined as ROA with knee pain worsening. The Cox proportional hazards models were used to assess the independent association between alcohol consumption and risk of knee.
During 96 months' follow-up, we identified 691 knees with incident ROA, and 496 knees with incident SxOA among 2,846 subjects. Compared to non-drinkers, excessive alcohol consumption was significantly associated with increased risk of ROA (HR = 1.93, 95% CI: 1.28-2.89) and SxOA (HR = 1.61, 95% CI: 1.04-2.48). Similar association was observed for liquor consumption (HR = 1.71, 95% CI: 1.16-2.52 for ROA; HR = 1.59, 95% CI: 1.04-2.39 for SxOA). Light to moderate alcohol consumption was not associated with knee OA risk.
Our results suggest that excessive alcohol drinking was associated with an increased risk of knee OA. Further studies are needed in other populations.
在一项大型前瞻性队列研究中，研究饮酒与膝关节骨关节炎（OA）发病风险的相关性。
在骨关节炎倡议中，2846 名年龄在 45-79 岁且基线时至少一侧膝关节无放射学膝关节 OA 的参与者，随访时间长达 96 个月。基线饮酒信息通过 Block Brief 食物频率问卷获得。膝关节放射学 OA（ROA）的发病病例定义为在随访期间 Kellgren-Lawrence 分级从 0 或 1 变为≥2。膝关节症状性 OA（SxOA）定义为 ROA 伴膝关节疼痛加重。使用 Cox 比例风险模型评估饮酒与膝关节发病风险之间的独立相关性。
在 96 个月的随访期间，在 2846 名受试者中，有 691 例膝关节出现新发 ROA，有 496 例膝关节出现新发 SxOA。与不饮酒者相比，过量饮酒与 ROA（HR=1.93，95%CI：1.28-2.89）和 SxOA（HR=1.61，95%CI：1.04-2.48）发病风险增加显著相关。同样观察到白酒消费的类似关联（ROA 的 HR=1.71，95%CI：1.16-2.52；SxOA 的 HR=1.59，95%CI：1.04-2.39）。轻度至中度饮酒与膝关节 OA 风险无关。
我们的研究结果表明，过量饮酒与膝关节 OA 风险增加相关。需要在其他人群中开展进一步的研究。
