Department of Oral Medicine, Dental Implants Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Dental Students Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
Gulf J Oncolog. 2021 Sep;1(37):42-47.
Oral mucositis is a common complication induced by radiation in head and neck cancer patients. OM can cause pain, dysphagia, dehydration and impaired quality of life. The main objective of this study was to assess the effectiveness of licorice mucoadhesive film on symptoms of head and neck radiotherapy-induced mucositis.
sixty head and neck cancer patients who have been scheduled to undergo radiotherapy were randomly assigned to receive radiotherapy plus licorice mucoadhesive film (30) or radiotherapy plus placebo mucoadhesive film. In this double blinded randomized clinical trial, oral mucositis was estimated by world health organization scales, a quantitative scale, and symptoms were evaluated by visual analog scale.
The results showed a meaningful difference in pain score between two groups in third and fourth weeks (P-value <0.05). Also, there was a significant difference in scale of mucositis between the two groups in weeks 3 and 4 (P-value <0.05). However, there were no meaningful differences with regard to pain and scale of mucositis in weeks 0, 1, 2. (P-value>0.05).
This study showed that licorice mucoadhesive film can be effective in decreasing pain and level of radiation-induced mucositis and it could be administered as an alternative agent in OM management. Key words: Oral mucositis, Radiotherapy, Licorice, Mucoadhesive film, Placebo.
口腔黏膜炎是头颈部癌症患者放疗的常见并发症。口腔黏膜炎可引起疼痛、吞咽困难、脱水和生活质量受损。本研究的主要目的是评估甘草黏膜黏附膜对放疗诱导的口腔黏膜炎症状的疗效。
将 60 名计划接受放疗的头颈部癌症患者随机分为放疗加甘草黏膜黏附膜组（30 名）或放疗加安慰剂黏膜黏附膜组。在这项双盲随机临床试验中，口腔黏膜炎采用世界卫生组织量表、定量量表进行评估，症状采用视觉模拟量表进行评估。
结果显示，第三和第四周两组患者的疼痛评分有显著差异（P 值<0.05）。此外，第三和第四周两组的黏膜炎量表也有显著差异（P 值<0.05）。然而，在第 0、1、2 周，疼痛和黏膜炎量表无显著差异（P 值>0.05）。
本研究表明，甘草黏膜黏附膜可有效减轻疼痛和放疗诱导的黏膜炎程度，可作为口腔黏膜炎管理的替代药物。关键词：口腔黏膜炎、放疗、甘草、黏膜黏附膜、安慰剂。
