Department of Hematology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jiangxi Key Laboratory of Clinical and Translational Cancer Research, Department of Oncology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Rejuvenation Res. 2022 Jun;25(3):149-157. doi: 10.1089/rej.2021.0022. Epub 2022 May 17.
Ultraviolet B (UVB) radiation may influence the occurrence or even worsen cutaneous disorders from inflammatory to neoplastic disorders. Dietary restriction (DR) is a well-known regimen that can retard aging-associated pathologies, and is shown by us and others that it can significantly inhibit inflammation under various conditions, including in both undisturbed and stressed settings. It is unknown whether DR could act as a nonpharmacological factor to protect skin against UVB-induced damage. In this study, we performed 30% DR to mice 1 week before UVB irradiation (798.6 mJ/cm). Remarkably, continuous DR significantly ameliorated UVB-induced skin damage and histological changes, associated with a great reduction in the inflammatory responses in the skin. Intriguingly, refed DR mice with diet even 24 hours postirradiation reinflamed the inflammatory responses and induced significantly strong damage to the skin. Together, this study provides the first experimental evidence that DR greatly protects mouse skin from high dose of UVB irradiation, which if translatable could have great implications in human beings.
紫外线 B（UVB）辐射可能会影响皮肤疾病的发生，甚至使炎症性到肿瘤性疾病恶化。饮食限制（DR）是一种众所周知的方法，可以延缓与衰老相关的病理变化，我们和其他人的研究表明，它可以在各种条件下显著抑制炎症，包括在未受干扰和应激的环境下。目前尚不清楚 DR 是否可以作为一种非药物因素来保护皮肤免受 UVB 诱导的损伤。在这项研究中，我们在 UVB 照射（798.6 mJ/cm）前一周对小鼠进行 30%的 DR。值得注意的是，持续的 DR 显著改善了 UVB 诱导的皮肤损伤和组织学变化，同时皮肤的炎症反应也大大减少。有趣的是，即使在辐照后 24 小时重新喂食 DR 饮食，也会重新引发炎症反应，并对皮肤造成明显强烈的损伤。总之，这项研究首次提供了实验证据，证明 DR 可以极大地保护小鼠皮肤免受大剂量 UVB 照射，这如果可以转化，将对人类产生重大影响。
