Shiel Robert E, Mooney Carmel T
School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
Canine Med Genet. 2022 Feb 14;9(1):1. doi: 10.1186/s40575-022-00114-9.
The year 2021 marked the centenary of the isolation of a therapeutic form of insulin and its successful use in dogs. This was a landmark moment that subsequently and rapidly led to the commercial manufacture of insulin for use in humans. The impact of insulin was almost miraculous as those destined to die from their diabetes mellitus returned to life. Over the past 100 years, insulin formulations have been modified to attempt to provide a predictable and prolonged duration of action while avoiding the development of hypoglycaemia. This has led to an ever-growing variety of insulin types in human medicine, many of which have subsequently been used in dogs. The purpose of this review article is to provide an overview of available insulin types and their application to the chronic management of canine diabetes mellitus.
2021年是一种治疗性胰岛素被分离出来并成功用于犬类的一百周年。这是一个具有里程碑意义的时刻，随后迅速促成了用于人类的胰岛素的商业化生产。胰岛素的影响几乎是奇迹般的，那些注定死于糖尿病的人重获新生。在过去的100年里，胰岛素制剂不断改进，试图提供可预测的、延长的作用时间，同时避免低血糖的发生。这导致了人类医学中胰岛素类型的不断增加，其中许多随后也被用于犬类。这篇综述文章的目的是概述现有的胰岛素类型及其在犬类糖尿病慢性管理中的应用。
