Phochantachinda Sataporn, Photcharatinnakorn Pongsakorn, Chatchaisak Duangthip, Sakcamduang Walasinee, Chansawhang Anchana, Buranasinsup Shutipen, Suemanotham Namphung, Chantong Boonrat
Department of Clinical Sciences and Public Health, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand.
Prasu Arthorn Animal Hospital, Faculty of Veterinary Science, Mahidol University, Nakhon Pathom, Thailand.
PLoS One. 2025 May 7;20(5):e0321509. doi: 10.1371/journal.pone.0321509. eCollection 2025.
The hyperglycemic state in diabetes mellitus induces oxidative stress and inflammation, contributing to diabetic tissue damage and associated complications. Astaxanthin, a potent antioxidant carotenoid, has been investigated for its potential to prevent and manage diabetes across various species; however, its effect on client-owned dogs remains poorly studied. This study explored the impact of astaxanthin supplementation on canine diabetes mellitus using a proteomics approach. A total of 18 client-owned dogs were enrolled: 6 dogs with diabetes mellitus and 12 clinically healthy dogs. The diabetic dogs received their standard treatment regimen along with daily oral supplementation of 12 mg of astaxanthin (1.5-2.4 mg/kg) for 90 days. Plasma samples were collected at the beginning and end of the study period for proteomics analysis. After astaxanthin supplementation, significant alterations in the expression of proteins associated with the complement system, coagulation cascade, JAK-STAT signaling, and protein kinase C signaling (all of which contribute to inflammation and oxidative stress) were observed. Astaxanthin exhibited potential for reducing diabetes-associated complications, such as insulin resistance, vascular dysfunction, nephropathy, and cardiac issues, even though it did not affect clinical parameters (hematology, plasma biochemistry, blood glucose, and serum fructosamine). These findings suggest that astaxanthin may be a valuable complementary therapy for managing diabetes-related complications in canines.
糖尿病中的高血糖状态会引发氧化应激和炎症，导致糖尿病组织损伤及相关并发症。虾青素是一种强效抗氧化类胡萝卜素，人们已对其在不同物种中预防和控制糖尿病的潜力进行了研究；然而，其对宠物犬的影响仍研究不足。本研究采用蛋白质组学方法探讨了补充虾青素对犬糖尿病的影响。共纳入18只宠物犬：6只患有糖尿病，12只临床健康。糖尿病犬接受标准治疗方案，并每日口服12毫克虾青素（1.5 - 2.4毫克/千克），持续90天。在研究期开始和结束时采集血浆样本进行蛋白质组学分析。补充虾青素后，观察到与补体系统、凝血级联反应、JAK - STAT信号传导和蛋白激酶C信号传导相关的蛋白质表达发生了显著变化（所有这些都与炎症和氧化应激有关）。尽管虾青素不影响临床参数（血液学、血浆生物化学、血糖和血清果糖胺），但它显示出降低糖尿病相关并发症的潜力，如胰岛素抵抗、血管功能障碍、肾病和心脏问题。这些发现表明，虾青素可能是管理犬糖尿病相关并发症的一种有价值的辅助疗法。
