Department of Biology, Duke University, Durham, NC, United States.
Curr Top Dev Biol. 2022;146:25-48. doi: 10.1016/bs.ctdb.2021.10.002. Epub 2021 Dec 3.
This review reports recent findings on the specification and patterning of neurons that establish the larval nervous system of the sea urchin embryo. Neurons originate in three regions of the embryo. Perturbation analyses enabled construction of gene regulatory networks controlling the several neural cell types. Many of the mechanisms described reflect shared features of all metazoans and others are conserved among deuterostomes. This nervous system with a very small number of neurons supports the feeding and swimming behaviors of the larva until metamorphosis when an adult nervous system replaces that system.
这篇综述报告了最近关于海胆胚胎幼虫神经系统建立过程中神经元的特化和模式形成的研究结果。神经元起源于胚胎的三个区域。通过扰动分析,构建了控制几种神经细胞类型的基因调控网络。描述的许多机制反映了所有后生动物的共同特征,而其他机制在后口动物中是保守的。这个拥有非常少量神经元的神经系统支持幼虫的摄食和游泳行为,直到变态期,此时一个成年神经系统取代了那个系统。