Onyema Michael C, Drakou Eftychia E, Dimitriadis Georgios K
Department of Endocrinology, King's College Hospital NHS Foundation Trust, Denmark Hill, London, SE5 9RS, UK.
Department of Clinical Oncology, Guy's Cancer Centre - Guy's and St Thomas' NHS Foundation Trust, Great Maze Pond, London, SE1 9RT, UK.
Best Pract Res Clin Endocrinol Metab. 2022 May;36(3):101621. doi: 10.1016/j.beem.2022.101621. Epub 2022 Feb 4.
Paraneoplastic syndromes denote rare but notable phenomena caused by the tumour mediated release of bioactive substances. Peptide and non-peptide hormone causes are explored with a particular focus on pathogenesis, symptoms, diagnosis and treatment. Early detection and management of paraneoplastic syndromes can improve morbidly and mortality; definitive treatment remains effective surgical or anti-tumour therapies. Pituitary autoimmunity may provide a novel presentation of paraneoplastic syndromes for which further research is warranted.
副肿瘤综合征是指由肿瘤介导释放生物活性物质引起的罕见但值得注意的现象。本文探讨了肽类和非肽类激素的致病原因，特别关注其发病机制、症状、诊断和治疗。副肿瘤综合征的早期检测和管理可以改善发病率和死亡率；确定性治疗仍然是有效的手术或抗肿瘤治疗。垂体自身免疫可能为副肿瘤综合征提供一种新的表现形式，对此值得进一步研究。
