Chen Xueping, Huang Yan, Bao Ting, Jia Fu, Ou Ruwei, Wei Qianqian, Chen Yongping, Liu Jiao, Yang Jing, Shang Huifang
West China Hospital, Sichuan University, Chengdu, China.
Front Aging Neurosci. 2022 Jan 28;13:790939. doi: 10.3389/fnagi.2021.790939. eCollection 2021.
Cystatin C is indicated to be involved in the pathogenesis of Alzheimer's disease (AD) and cognitive impairment. Our objective is to examine the serum Cystatin C levels, and to clarify the correlations between serum Cystatin C and cognitive performance in Chinese AD patients.
The serum Cystatin C concentrations in AD patients and age, sex, and body mass index (BMI) matched-healthy controls were measured. The cognitive functions of the AD patients were evaluated by using the Mini-mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). The severity of dementia was determined with clinical dementia rating (CDR).
A total of 463 AD patients and 1,389 matched healthy subjects were included. AD patients had higher serum Cystatin C than healthy controls. Serum cystatin C levels were correlated with MoCA scores in AD patients. In an ordinal logistic regression model, AD patients with higher serum cystatin C levels had increased odds of severe cognitive dysfunction.
Our study suggested that AD patients had higher levels of serum cystatin C than age/sex/BMI-matched normal control subjects. Higher serum cystatin C may be associated with worse cognitive performance, but more studies are required to verify such association.
有迹象表明胱抑素C参与阿尔茨海默病(AD)的发病机制及认知障碍过程。我们的目的是检测中国AD患者的血清胱抑素C水平,并阐明血清胱抑素C与认知表现之间的相关性。
检测AD患者及年龄、性别、体重指数(BMI)相匹配的健康对照者的血清胱抑素C浓度。采用简易精神状态检查表(MMSE)和蒙特利尔认知评估量表(MoCA)对AD患者的认知功能进行评估。用临床痴呆评定量表(CDR)确定痴呆的严重程度。
共纳入463例AD患者和1389例相匹配的健康受试者。AD患者的血清胱抑素C水平高于健康对照者。AD患者的血清胱抑素C水平与MoCA评分相关。在有序逻辑回归模型中,血清胱抑素C水平较高的AD患者出现严重认知功能障碍的几率增加。
我们的研究表明,AD患者血清胱抑素C水平高于年龄/性别/BMI相匹配的正常对照受试者。血清胱抑素C水平较高可能与较差的认知表现相关,但需要更多研究来验证这种关联。