Suppr超能文献

阿尔茨海默病患者血清胱抑素C水平的变化及其与认知功能的关系。

Changes in Serum Cystatin C Levels and the Associations With Cognitive Function in Alzheimer's Disease Patients.

作者信息

Chen Xueping, Huang Yan, Bao Ting, Jia Fu, Ou Ruwei, Wei Qianqian, Chen Yongping, Liu Jiao, Yang Jing, Shang Huifang

机构信息

West China Hospital, Sichuan University, Chengdu, China.

出版信息

Front Aging Neurosci. 2022 Jan 28;13:790939. doi: 10.3389/fnagi.2021.790939. eCollection 2021.

Abstract

BACKGROUND AND OBJECTIVE

Cystatin C is indicated to be involved in the pathogenesis of Alzheimer's disease (AD) and cognitive impairment. Our objective is to examine the serum Cystatin C levels, and to clarify the correlations between serum Cystatin C and cognitive performance in Chinese AD patients.

METHODS

The serum Cystatin C concentrations in AD patients and age, sex, and body mass index (BMI) matched-healthy controls were measured. The cognitive functions of the AD patients were evaluated by using the Mini-mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). The severity of dementia was determined with clinical dementia rating (CDR).

RESULTS

A total of 463 AD patients and 1,389 matched healthy subjects were included. AD patients had higher serum Cystatin C than healthy controls. Serum cystatin C levels were correlated with MoCA scores in AD patients. In an ordinal logistic regression model, AD patients with higher serum cystatin C levels had increased odds of severe cognitive dysfunction.

CONCLUSION

Our study suggested that AD patients had higher levels of serum cystatin C than age/sex/BMI-matched normal control subjects. Higher serum cystatin C may be associated with worse cognitive performance, but more studies are required to verify such association.

摘要

背景与目的

有迹象表明胱抑素C参与阿尔茨海默病(AD)的发病机制及认知障碍过程。我们的目的是检测中国AD患者的血清胱抑素C水平,并阐明血清胱抑素C与认知表现之间的相关性。

方法

检测AD患者及年龄、性别、体重指数(BMI)相匹配的健康对照者的血清胱抑素C浓度。采用简易精神状态检查表(MMSE)和蒙特利尔认知评估量表(MoCA)对AD患者的认知功能进行评估。用临床痴呆评定量表(CDR)确定痴呆的严重程度。

结果

共纳入463例AD患者和1389例相匹配的健康受试者。AD患者的血清胱抑素C水平高于健康对照者。AD患者的血清胱抑素C水平与MoCA评分相关。在有序逻辑回归模型中,血清胱抑素C水平较高的AD患者出现严重认知功能障碍的几率增加。

结论

我们的研究表明,AD患者血清胱抑素C水平高于年龄/性别/BMI相匹配的正常对照受试者。血清胱抑素C水平较高可能与较差的认知表现相关,但需要更多研究来验证这种关联。

相似文献

1
Changes in Serum Cystatin C Levels and the Associations With Cognitive Function in Alzheimer's Disease Patients.
Front Aging Neurosci. 2022 Jan 28;13:790939. doi: 10.3389/fnagi.2021.790939. eCollection 2021.
4
Long-term Physical Exercise Improves Finger Tapping of Patients with Alzheimer's Disease.
Curr Alzheimer Res. 2021;18(14):1077-1086. doi: 10.2174/1567205018666211215150157.
5
Cystatin C predicts cognitive decline in multiple system atrophy: A 1-year prospective cohort study.
Front Aging Neurosci. 2022 Nov 28;14:1069837. doi: 10.3389/fnagi.2022.1069837. eCollection 2022.
9
Association between subfield volumes of the medial temporal lobe and cognitive assessments.
Heliyon. 2019 Jun 4;5(6):e01828. doi: 10.1016/j.heliyon.2019.e01828. eCollection 2019 Jun.

引用本文的文献

1
Psoriasis Does Not Seem to Impair Glomerular and Tubular Function - The Comprehensive Study on Serum and Urine.
Psoriasis (Auckl). 2025 Jul 18;15:285-299. doi: 10.2147/PTT.S530313. eCollection 2025.
4
Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats.
Sci Rep. 2024 Apr 10;14(1):8441. doi: 10.1038/s41598-024-59013-7.
7
Cystatin C is associated with poor survival in amyotrophic lateral sclerosis patients.
Front Neurosci. 2024 Jan 5;17:1309568. doi: 10.3389/fnins.2023.1309568. eCollection 2023.

本文引用的文献

1
Kidney Function Is Not Related to Brain Amyloid Burden on PET Imaging in The 90+ Study Cohort.
Front Med (Lausanne). 2021 Sep 20;8:671945. doi: 10.3389/fmed.2021.671945. eCollection 2021.
2
Cystatin C, cognition, and brain MRI findings in 90+-year-olds.
Neurobiol Aging. 2020 Sep;93:78-84. doi: 10.1016/j.neurobiolaging.2020.04.022. Epub 2020 Apr 29.
4
Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer's disease.
Alzheimers Dement (Amst). 2018 Jun 21;10:429-437. doi: 10.1016/j.dadm.2018.05.006. eCollection 2018.
6
A systemic view of Alzheimer disease - insights from amyloid-β metabolism beyond the brain.
Nat Rev Neurol. 2017 Sep 29;13(10):612-623. doi: 10.1038/nrneurol.2017.111.
8
Estimated GFR, Albuminuria, and Cognitive Performance: The Maastricht Study.
Am J Kidney Dis. 2017 Feb;69(2):179-191. doi: 10.1053/j.ajkd.2016.04.017. Epub 2016 Jun 10.
9
Cystatin C and cognitive impairment 10 years later in older women.
J Gerontol A Biol Sci Med Sci. 2015 Jun;70(6):771-8. doi: 10.1093/gerona/glu189. Epub 2014 Nov 1.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验