Department of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Immunol. 2022 Jan 27;13:817942. doi: 10.3389/fimmu.2022.817942. eCollection 2022.
Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of immature myeloid cells and exhibit obvious immunomodulatory functions. Exosomes released by MDSCs (MDSCs-Exos) have similar effects to parental MDSCs in regulating tumor immunity. In this review, we provided a comprehensive description of the characteristics, functions and mechanisms of exosomes. We analyzed the immunosuppressive, angiogenesis and metastatic effects of MDSCs-Exos in different tumors through multiple perspectives. Immunotherapy targeting MDSCs-Exos has demonstrated great potential in cancers and non-cancerous diseases.
肿瘤免疫涉及恶性肿瘤的进展。髓系来源的抑制性细胞（MDSCs）在肿瘤免疫中发挥着不可替代的作用。MDSCs 由未成熟的髓系细胞组成，具有明显的免疫调节功能。MDSCs 释放的外泌体（MDSCs-Exos）在调节肿瘤免疫方面与亲本 MDSCs 具有相似的作用。在这篇综述中，我们全面描述了外泌体的特征、功能和机制。我们从多个角度分析了 MDSCs-Exos 在不同肿瘤中的免疫抑制、血管生成和转移作用。针对 MDSCs-Exos 的免疫疗法在癌症和非癌症疾病中显示出巨大的潜力。
