髓源性抑制细胞在癌症和免疫治疗中的免疫抑制作用。
Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy.
机构信息
Cancer Research Laboratory Program, Lawson Health Research Institute, London, ON N6A5 W9, Canada.
Department of Pathology and Laboratory Medicine, University of Western Ontario, London, ON N6A 3K7, Canada.
出版信息
Cells. 2021 May 11;10(5):1170. doi: 10.3390/cells10051170.
The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in suppressing anti-tumor immunity. Overcoming the suppressive effects of MDSCs is a major hurdle in cancer immunotherapy. Therefore, understanding the mechanisms by which MDSCs promote tumor growth is essential for improving current immunotherapies and developing new ones. This review explores mechanisms by which MDSCs suppress T-cell immunity and how this impacts the efficacy of commonly used immunotherapies.
髓系细胞的主要功能是保护宿主免受感染。然而，在癌症进展或慢性炎症状态下，这些细胞会发育成髓系来源的抑制细胞（MDSC），它们在抑制抗肿瘤免疫方面发挥着重要作用。克服 MDSC 的抑制作用是癌症免疫治疗的主要障碍。因此，了解 MDSC 促进肿瘤生长的机制对于改进当前的免疫疗法和开发新的免疫疗法至关重要。本综述探讨了 MDSC 如何抑制 T 细胞免疫以及这如何影响常用免疫疗法的疗效。
Zotero 插件