川崎病的临床表现和实验室检查:超越经典诊断特征。
Clinical Manifestations and Laboratory Findings of Kawasaki Disease: Beyond the Classic Diagnostic Features.
机构信息
Department of Pediatric, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
Department of Pediatric, Hospital Wanita dan Kanak Kanak Sabah, Kota Kinabalu 88996, Malaysia.
出版信息
Medicina (Kaunas). 2022 May 30;58(6):734. doi: 10.3390/medicina58060734.
Kawasaki disease (KD) has shown a marked increase in trend over the globe, especially within the last two decades. Kawasaki disease is often seen in the paediatric population below five years old, while it is rare for those who are beyond that age. Up to this date, no exact causes has been identified although KD was found more than half a century ago. The underlying pathogenesis of the disease is still unelucidated, and researchers are trying to unlock the mystery of KD. To further complicate the diagnosis and the prompt management, a specific biomarker for the diagnosis of KD is yet to be discovered, making it hard to differentiate between KD and other diseases with a similar presentation. Nonetheless, since its discovery, clinicians and scientists alike had known more about the different clinical aspects of typical KD. Thus, this article intends to revisit and review the various clinical manifestations and laboratory characteristics of KD in order to guide the diagnosis of KD.
川崎病(KD)在全球范围内呈明显上升趋势,尤其是在过去的二十年中。川崎病多见于五岁以下的儿童,而五岁以上的儿童则较为少见。尽管川崎病在半个多世纪前就已被发现,但目前仍未确定其确切病因。该病的发病机制尚不清楚,研究人员正在试图揭开川崎病的奥秘。由于尚未发现用于川崎病诊断的特定生物标志物,进一步增加了诊断和及时治疗的难度,难以将川崎病与其他表现相似的疾病区分开来。尽管如此,自发现以来,临床医生和科学家已经对典型川崎病的不同临床方面有了更多的了解。因此,本文旨在重新审视和回顾川崎病的各种临床表现和实验室特征,以指导川崎病的诊断。