Saberi Alia, Akhondzadeh Shahin, Kazemi Samira, Kazemi Samaneh
Department of Neurology, Neuroscience Research Center, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Basic Clin Neurosci. 2021 Jul-Aug;12(4):427-440. doi: 10.32598/bcn.2021.1324.2. Epub 2021 Jul 1.
A major cause of injury and the second cause of death worldwide is stroke. Among several infectious agents considered as the risk factor of stroke, some pathogens demonstrated stronger robust associations with stroke. Proposing an accurate correlation between infectious microorganisms and stroke provides valuable information for early intervention and control of the infections.
In this study, we searched the literature using the Web of Science, PMC/Medline via PubMed, and Scopus databases up to July 2018 without time and language restrictions. After quality assessment, 16 articles were included in the study. The whole data extraction process was independently conducted by two reviewers.
Based on the results of the studies, viruses, such as Hepatitis C virus (HCV), Hepatitis B virus (HBV), Human Immunodeficiency Virus (HIV), Herpes Simplex Virus Type-1, 2 (HSV-1, 2), Varicella-Zoster Virus (VZV or Chickenpox), and West Nile virus (WNV) seem to be common causes of ischemic stroke. Moreover, the association of other microbial categories, such as Streptococcus mutans (in bacteria), Toxocara spp. and Toxoplasma gondii (in parasites), and Rhizopus sp. (in fungi) with stroke was reported.
Considering the adverse role of the above-mentioned microorganisms, it is necessary to implement some preventive measures for stroke treatment.
中风是全球范围内受伤的主要原因及第二大致死原因。在被视为中风风险因素的多种感染因子中，一些病原体与中风的关联更为紧密。提出感染性微生物与中风之间的准确关联，可为感染的早期干预和控制提供有价值的信息。
在本研究中，我们使用科学网、通过PubMed检索的PMC/Medline以及Scopus数据库检索截至2018年7月的文献，无时间和语言限制。经过质量评估，16篇文章被纳入研究。整个数据提取过程由两名审阅者独立进行。
基于研究结果，病毒，如丙型肝炎病毒（HCV）、乙型肝炎病毒（HBV）、人类免疫缺陷病毒（HIV）、单纯疱疹病毒1型、2型（HSV - 1、2）、水痘带状疱疹病毒（VZV或水痘）和西尼罗河病毒（WNV）似乎是缺血性中风的常见病因。此外，还报道了其他微生物类别与中风的关联，如变形链球菌（细菌类）、弓蛔虫属和刚地弓形虫（寄生虫类）以及根霉菌属（真菌类）。
考虑到上述微生物的不利作用，有必要实施一些中风治疗的预防措施。
