Saberi Alia, Roudbary Seyed-Ali, Ghayeghran Amirreza, Kazemi Samaneh, Hosseininezhad Mozaffar
Neurosciences Research Center, Department of Neurology, Pouursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Basic Clin Neurosci. 2018 Mar-Apr;9(2):73-86. doi: 10.29252/nirp.bcn.9.2.73.
Bacterial meningitis is an acute infectious inflammation of the protective membranes covering the brain. Its early diagnosis is vital because of its high morbidity and mortality. It is mostly diagnosed by a gold standard diagnostic tool i.e. Cerebrospinal Fluid (CSF) analysis. However, it is sometimes difficult and or impossible to do this procedure and an alternative diagnostic tool is needed. Contrast enhanced magnetic resonance imaging can detect the pus or other changes in subarachnoid space. But our optimal aim is to use an imaging method without using contrast to be useable and available in more specific condition.
This study aimed to survey the role of non-contrast Magnetic Resonance Imaging (MRI) in the diagnosis of the bacterial meningitis. MEDLINE/PubMed Central, Web of Science and Scopus were searched without time period and language limitation until March 2017. We found 6410 papers in our initial search. After assessing the content of the papers based on Cochrane library guidelines and inclusion/exclusion criteria, 6 relevant studies were included in the systematic review. All of included studies were observational studies.
MRI studies demonstrated that Fluid Attenuation Inversion Recovery (FLAIR) and Diffusion-Weighted Image (DWI) MR imaging among all MRI modalities can detect some abnormalities compatible with bacterial meningitis. FLAIR and DWI-MR imaging are potentially useful to diagnose bacterial meningitis and can be used in emergent condition in which bacterial meningitis is highly suspicious and the other diagnostic tools are not available or feasible.
细菌性脑膜炎是覆盖大脑的保护膜的急性感染性炎症。由于其高发病率和高死亡率，早期诊断至关重要。它大多通过金标准诊断工具即脑脊液（CSF）分析来诊断。然而，有时进行该操作困难或不可能，因此需要一种替代诊断工具。对比增强磁共振成像可以检测蛛网膜下腔的脓液或其他变化。但我们的最佳目标是使用一种无需使用造影剂的成像方法，以便在更特定的情况下可用且可行。
本研究旨在探讨非对比磁共振成像（MRI）在细菌性脑膜炎诊断中的作用。检索了MEDLINE/PubMed Central、科学网和Scopus，检索时间无限制，语言不限，截至2017年3月。我们在初始检索中找到6410篇论文。根据Cochrane图书馆指南和纳入/排除标准评估论文内容后，6项相关研究被纳入系统评价。所有纳入研究均为观察性研究。
MRI研究表明，在所有MRI模式中，液体衰减反转恢复（FLAIR）和扩散加权成像（DWI）磁共振成像可以检测到一些与细菌性脑膜炎相符的异常。FLAIR和DWI磁共振成像对诊断细菌性脑膜炎可能有用，可用于细菌性脑膜炎高度可疑且其他诊断工具不可用或不可行的紧急情况。
