Seitz W, Fritz K, Aeikens B, Kirchner E
Reg Anaesth. 1986 Jan;9(1):18-21.
The effects of 0.5% bupivacaine-CO2 and bupivacaine-HCl were tested in a prospective randomised trial on 16 patients who underwent extracorporal shock wave lithotripsy (ESWL) with epidural analgesia. A shorter time of onset of analgesia (3.75 +/- 0.51 min) and a faster distribution of analgesia were noted with bupivacaine-CO2. Hypoalgesic regions were not registered with bupivacaine-CO2 nor with bupivacaine-HCl under shock wave treatment. About thirty minutes after application of either substance a level 1 block according to Bromage was noted, which was not desirable during positioning of the patient on the hydraulic lithotriptor chair. However, toxic blood levels were not reached in either group of patients to any extent.
在一项前瞻性随机试验中，对16例行体外冲击波碎石术（ESWL）并采用硬膜外镇痛的患者，测试了0.5%布比卡因 - 二氧化碳和盐酸布比卡因的效果。布比卡因 - 二氧化碳组的镇痛起效时间较短（3.75±0.51分钟），且镇痛分布更快。在冲击波治疗下，布比卡因 - 二氧化碳组和盐酸布比卡因组均未出现痛觉减退区域。使用任何一种药物约30分钟后，根据 Bromage分级出现了1级阻滞，这在将患者放置在液压碎石椅上进行定位时是不理想的。然而，两组患者均未在任何程度上达到中毒血药浓度。
