Ijaz Muhammad, Arshad Asma, Awan Muhammad Ahmad, Tariq Muhammad Rizwan, Ali Shinawar Waseem, Ali Sajid, Shafiq Muhammad, Ahmed Saeed, Sheas Muhammad Naveed, Iftikhar Madiha, Ahmed Sheraz, Nasir Muhammad Adnan, Kausar Ghazala, Javed Ammad Ul Islam, Safdar Waseem
National Institute of Food Science and Technology University of Agriculture Faisalabad Faisalabad Pakistan.
Quaid-e-Azam Medical College Bahawalpur Pakistan.
Food Sci Nutr. 2021 Dec 13;10(2):499-506. doi: 10.1002/fsn3.2683. eCollection 2022 Feb.
Herbal drugs play an imperative role in healthcare programs in developing countries. Curry leaves have wide medicinal importance and are used to treat various diseases traditionally. The current study was carried out to estimate the extent of mercury toxicity and the potential effect of curry leaves against defined toxicity. The study group comprised 24 rats weighing between 130 and150 g. Group 1 was kept normal, and group 2 was exposed to mercury at 0.4 mg/kg of body weight in the form of mercuric chloride (HgCl). The group 3 animals were treated with curry leaves with a dosage of 300 mg/kg of body weight. Group 4 was treated with curry leaves along with mercury with a dosage of 300 and 0.4 mg/kg consecutively. After 28 days, the rats were killed. Blood sample of all groups were evaluated separately to determine the results of different parameters. The results show that ALP, AST, ALT, urea, bilirubin, and creatinine increased with mercury application and decreased with curry leaf exposure. SOD, CAT, GPx, and GR of the liver as well as the kidney depleted on mercury exposure whereas they increased with curry leaf application. HDL increased with curry leaf application and decreased with mercury treatment, while LDL, triglyceride, and cholesterol decreased with curry leaves and increased with mercury exposure. Organ index in mercury along with curry leaf application got close to normal.
草药在发展中国家的医疗保健项目中发挥着至关重要的作用。咖喱叶具有广泛的药用价值，传统上用于治疗各种疾病。本研究旨在评估汞毒性的程度以及咖喱叶对特定毒性的潜在影响。研究组由24只体重在130至150克之间的大鼠组成。第1组保持正常，第2组以氯化汞（HgCl）的形式按0.4毫克/千克体重暴露于汞。第3组动物用剂量为300毫克/千克体重的咖喱叶进行治疗。第4组连续用剂量为300毫克/千克和0.4毫克/千克的咖喱叶和汞进行治疗。28天后，处死大鼠。分别对所有组的血样进行评估以确定不同参数的结果。结果表明，碱性磷酸酶（ALP）、天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）、尿素、胆红素和肌酐随着汞的施用而增加，随着咖喱叶的暴露而降低。肝脏和肾脏的超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）和谷胱甘肽还原酶（GR）在汞暴露时减少，而随着咖喱叶的施用而增加。高密度脂蛋白（HDL）随着咖喱叶的施用而增加，随着汞处理而降低，而低密度脂蛋白（LDL）、甘油三酯和胆固醇随着咖喱叶而降低，随着汞暴露而增加。汞与咖喱叶一起施用时的器官指数接近正常。
