Hossein-Khannazer Nikoo, Kazem Arki Mandana, Keramatinia Aliasghar, Rezaei-Tavirani Mostafa
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Lasers Med Sci. 2021 Dec 28;12:e88. doi: 10.34172/jlms.2021.88. eCollection 2021.
Multiple sclerosis (MS) is an autoimmune disease. Inflammatory cells, cytokines and chemokines play a major role in the pathogenesis of the disease. Low-level laser therapy (LLLT) as a photobiostimulation approach could affect a wide range of cellular responses. LLLT inhibits the inflammatory signaling pathway, improves cell viability, inhibits apoptosis, modulates immune responses and induces the production of growth factors. In this review, we discuss the effect of LLLT on cellular responses and its application in the treatment of MS. Such keywords as "low-level laser therapy", "photobiomodulation" and "multiple sclerosis" were used to find studies related to laser therapy in MS in Google scholar, PubMed and Medline databases. LLLT reduced the inflammatory immune cells and mediators. It also enhanced the regeneration of neurons. Investigations showed that besides current treatment strategies, LLLT could be a promising therapeutic approach for the treatment of MS.
多发性硬化症（MS）是一种自身免疫性疾病。炎症细胞、细胞因子和趋化因子在该疾病的发病机制中起主要作用。低强度激光疗法（LLLT）作为一种光生物刺激方法，可影响广泛的细胞反应。LLLT抑制炎症信号通路，提高细胞活力，抑制细胞凋亡，调节免疫反应并诱导生长因子的产生。在本综述中，我们讨论了LLLT对细胞反应的影响及其在MS治疗中的应用。使用“低强度激光疗法”、“光生物调节”和“多发性硬化症”等关键词在谷歌学术、PubMed和Medline数据库中查找与MS激光治疗相关的研究。LLLT减少了炎症免疫细胞和介质。它还增强了神经元的再生。研究表明，除了目前的治疗策略外，LLLT可能是一种有前景的MS治疗方法。
