Vafaei-Nezhad Saeed, Niknazar Somayeh, Payvandi Ali Asghar, Shirazi Tehrani Atefeh, Ahmady Roozbahany Navid, Ahrabi Behnaz, Abbaszadeh Hojjat Allah, Darabi Shahram
Department of Anatomical Sciences, School of Medicine, Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Lasers Med Sci. 2022 Jul 27;13:e32. doi: 10.34172/jlms.2022.32. eCollection 2022.
Multiple sclerosis (MS) is one of the autoimmune and chronic diseases of the central nervous system; this disease occurs more frequently in young people and women and leads to neurological symptoms. Oxidative stress, inflammatory processes, and oligodendrocyte dysfunction have a pivotal role in the pathophysiology of this disease. Nowadays it is reported that photobiomodulation (PBM) as a non-invasive treatment has neuroprotective potential, but the exact mechanisms are not understood. In this study, we reviewed the effects of PBM on MS. In this regard, we used the keywords "Photobiomodulation", "Laser therapy", and "Low-level laser therapy" on MS to find related studies on this subject in PubMed, Google scholar, Elsevier, Medline, and Scopus databases. PBM has positive effects on MS by regulating the inflammatory process, controlling immune cell activity and mitochondrial functions, as well as inhibiting free radicals production which finally leads to a reduction in neurological defects and an improvement in the functional status of patients. Overall, researchers have suggested the use of laser therapy in neurodegenerative diseases due to its numerous therapeutic effects.
多发性硬化症（MS）是中枢神经系统的自身免疫性慢性疾病之一；这种疾病在年轻人和女性中更为常见，并会导致神经症状。氧化应激、炎症过程和少突胶质细胞功能障碍在该疾病的病理生理学中起关键作用。如今有报道称，光生物调节（PBM）作为一种非侵入性治疗方法具有神经保护潜力，但其确切机制尚不清楚。在本研究中，我们综述了PBM对MS的影响。为此，我们在PubMed、谷歌学术、爱思唯尔、医学在线和Scopus数据库中使用关键词“光生物调节”“激光疗法”和“低强度激光疗法”以及“MS”来查找关于该主题的相关研究。PBM通过调节炎症过程、控制免疫细胞活性和线粒体功能以及抑制自由基产生，对MS产生积极影响，最终导致神经缺陷减少和患者功能状态改善。总体而言，由于其众多治疗效果，研究人员建议在神经退行性疾病中使用激光疗法。
