前列腺癌患者与健康对照个体的循环真菌微生物组差异。
Differential Circulating Fungal Microbiome in Prostate Cancer Patients Compared to Healthy Control Individuals.
机构信息
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, 29425 SC, USA.
Department of Urology, Capital Medical University Affiliated XuanWu Hospital, 45 Changchun Street, Xicheng District, Beijing 100053, China.
出版信息
J Immunol Res. 2022 Feb 3;2022:2574964. doi: 10.1155/2022/2574964. eCollection 2022.
BACKGROUNDS
Infection and inflammation play an important role in prostate cancer (PCa) etiology and pathogenesis. However, the environmental drivers for PCa are not fully understood.
METHODS
In a cross-sectional study, we analyzed circulating fungal microbiome in plasma samples from age and race-matched healthy control men ( = 34) and preoperative PCa patients ( = 31).
RESULTS
The fungal community in the plasma exhibited differences between individuals with PCa and healthy controls according to the beta diversity; there was no difference in the alpha diversity. Moreover, the relative abundance of several fungi differed between the two study groups from the class to species levels. The most significant differences were family, family, and species, which were enriched in PCa patients compared to controls. The increased was associated with low prostate-specific antigen (PSA) levels, increased class was associated with severe pathological stage, and decreased species was associated with disease relapse, compared to corresponding controls. Several fungi from class to species levels were increased in the controls compared to patients.
CONCLUSION
This is the first study to show plasma distinct fungal microbiome and its associations with PSA levels, relapse, and pathology stages in PCa patients.
背景
感染和炎症在前列腺癌（PCa）的病因和发病机制中起着重要作用。然而，PCa 的环境驱动因素尚未完全了解。
方法
在一项横断面研究中，我们分析了年龄和种族匹配的健康对照组男性（n=34）和术前 PCa 患者（n=31）的血浆样本中的循环真菌微生物组。
结果
根据 beta 多样性，PCa 患者和健康对照组的血浆真菌群落存在差异；alpha 多样性没有差异。此外，从纲到种水平，两组之间的几种真菌的相对丰度存在差异。最显著的差异是 科、 科和 种，与对照组相比，PCa 患者中这些真菌更为丰富。与相应的对照组相比，增加的 与低前列腺特异性抗原（PSA）水平相关，增加的 纲与严重的病理分期相关，而减少的 种与疾病复发相关。与患者相比，对照组中从纲到种水平的几种真菌增加。
结论
这是第一项研究表明，血浆中存在独特的真菌微生物组及其与 PCa 患者 PSA 水平、复发和病理分期的关联。
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