Manini Claudia, Larrinaga Gorka, Angulo Javier C, López José I
Department of Pathology, San Giovanni Bosco Hospital, ASL Città di Torino, 10154 Turin, Italy.
Department of Nursing, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.
Cancers (Basel). 2025 Mar 31;17(7):1173. doi: 10.3390/cancers17071173.
Urogenital cancer is very common in the male population of Western countries, a problem of major concern for public health systems, and a frequent test subject for oncological research. In this narrative, we identify the main hot topics for clinics and the basic science of urological cancer in the last few years (from 2021 onwards), considering the information given in the abstracts of almost 300 original articles published in outstanding journals of pathology, urology, and basic science. Once defined, for the top ten list of hot topics (the 2022 WHO update on the classification of urinary and male genital tumors, new entities in kidney cancer, urinary cancer-omics, update on the Gleason grading system, targeted therapies and other novel therapies in renal cancer, news on non-muscle invasive urothelial carcinoma, artificial intelligence in urologic cancer, intratumor heterogeneity influence in therapeutic failures in urologic neoplasms, intratumor microbiome and its influence in urologic tumor aggressiveness, and ecological principles and mathematics applied to urogenital cancer study), each issue is independently reviewed in an attempt to put together the most relevant updates and/or useful features accompanied by selected illustrations. This review article addresses some of the most interesting and current hot spots in urogenital basic cancer research and clinics and is mainly aimed toward clinicians, including pathologists, urologists, and oncologists. Readers are invited to explore each topic for further, more detailed information, in addition to the references provided.
泌尿生殖系统癌症在西方国家男性人群中非常常见，这是公共卫生系统主要关注的问题，也是肿瘤学研究中经常涉及的测试对象。在本文中，我们根据发表在病理学、泌尿学和基础科学领域优秀期刊上的近300篇原创文章摘要中的信息，确定了过去几年（从2021年起）泌尿生殖系统癌症临床和基础科学的主要热点话题。一旦确定，对于十大热点话题列表（2022年世界卫生组织关于泌尿系统和男性生殖系统肿瘤分类的更新、肾癌的新实体、泌尿系统癌症组学、Gleason分级系统的更新、肾癌的靶向治疗和其他新疗法、非肌层浸润性尿路上皮癌的新进展、泌尿生殖系统癌症中的人工智能、肿瘤内异质性对泌尿生殖系统肿瘤治疗失败的影响、肿瘤内微生物群及其对泌尿生殖系统肿瘤侵袭性的影响，以及应用于泌尿生殖系统癌症研究的生态学原理和数学），我们对每个问题进行了独立回顾，试图汇总最相关的更新内容和/或有用的特点，并配有精选插图。这篇综述文章探讨了泌尿生殖系统基础癌症研究和临床中一些最有趣和当前的热点问题，主要面向临床医生，包括病理学家、泌尿科医生和肿瘤学家。除了提供的参考文献外，还邀请读者进一步探索每个主题以获取更详细的信息。
