Abdollahzadeh Fatemeh, Khoshdel-Rad Niloofar, Moghadasali Reza
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Developmental Biology, University of Science and Culture, Tehran, Iran.
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran; Department of Developmental Biology, University of Science and Culture, Tehran, Iran.
Differentiation. 2022 Mar-Apr;124:28-42. doi: 10.1016/j.diff.2022.02.001. Epub 2022 Feb 9.
The extracellular matrix (ECM) is an essential network entity surrounding and supporting cells to guarantee their physiological function and homeostasis. It is important to choose the most appropriate ECM for in vitro experiments of mammalian cells for tissue engineering and functional analyses. Although most studies have examined optimization of the correct ECM that can be used to assess mammalian cells, a comprehensive study has not been conducted. In this review, we present the factors to be taken into consideration when designing or optimizing an appropriate ECM for development and maintenance of kidney tissues and compare the previously reported ECMs.
细胞外基质（ECM）是围绕并支持细胞以确保其生理功能和内环境稳定的重要网络实体。为进行组织工程和功能分析而选择最适合用于哺乳动物细胞体外实验的ECM非常重要。尽管大多数研究都考察了可用于评估哺乳动物细胞的正确ECM的优化，但尚未进行全面研究。在本综述中，我们阐述了在设计或优化用于肾脏组织发育和维持的合适ECM时应考虑的因素，并比较了先前报道的ECM。
