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Long-term neuropsychological outcomes of survivors of young childhood brain tumors treated on the Head Start II protocol.采用“启智II方案”治疗的幼儿脑肿瘤幸存者的长期神经心理学预后。
Neurooncol Pract. 2021 May 18;8(5):609-619. doi: 10.1093/nop/npab028. eCollection 2021 Oct.
2
Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).调整风险适应治疗的儿童髓母细胞瘤的临床和分子特征的结果：一项国际 III 期试验（SJMB03）的结果。
J Clin Oncol. 2021 Mar 1;39(7):822-835. doi: 10.1200/JCO.20.01372. Epub 2021 Jan 6.
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Prognostic relevance of clinical and molecular risk factors in children with high-risk medulloblastoma treated in the phase II trial PNET HR+5.高危型髓母细胞瘤患儿在 II 期试验 PNET HR+5 中的临床和分子危险因素的预后相关性。
Neuro Oncol. 2021 Jul 1;23(7):1163-1172. doi: 10.1093/neuonc/noaa301.
4
Association of Hearing Impairment With Neurocognition in Survivors of Childhood Cancer.儿童癌症幸存者听力损伤与神经认知的相关性。
JAMA Oncol. 2020 Sep 1;6(9):1363-1371. doi: 10.1001/jamaoncol.2020.2822.
5
Neuropsychological outcomes on Head Start III: a prospective, multi-institutional clinical trial for young children diagnosed with malignant brain tumors.“启智计划”三期的神经心理学结果：一项针对诊断为恶性脑肿瘤的幼儿的前瞻性多机构临床试验。
Neurooncol Pract. 2020 Jun;7(3):329-337. doi: 10.1093/nop/npz071. Epub 2020 Feb 3.
6
Changes in glomerular filtration rate and clinical course after sequential doses of carboplatin in children with embryonal brain tumors undergoing autologous stem cell transplantation.儿童胚胎性脑肿瘤患者自体干细胞移植后序贯卡铂剂量治疗对肾小球滤过率的变化及临床转归。
J Egypt Natl Canc Inst. 2020 Feb 18;32(1):9. doi: 10.1186/s43046-020-00024-6.
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Nonmetastatic Medulloblastoma of Early Childhood: Results From the Prospective Clinical Trial HIT-2000 and An Extended Validation Cohort.儿童早期非转移性髓母细胞瘤：前瞻性临床试验 HIT-2000 及扩展验证队列的结果。
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Excellent outcome of young children with nodular desmoplastic medulloblastoma treated on "Head Start" III: a multi-institutional, prospective clinical trial.“Head Start”III 方案治疗儿童结节性促纤维增生型髓母细胞瘤的良好转归：一项多机构前瞻性临床试验。
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9
Efficacy of High-Dose Chemotherapy and Three-Dimensional Conformal Radiation for Atypical Teratoid/Rhabdoid Tumor: A Report From the Children's Oncology Group Trial ACNS0333.大剂量化疗和三维适形放疗治疗非典型畸胎样/横纹肌样瘤的疗效：儿童肿瘤学组 ACNS0333 试验报告。
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10
Phase II Study of Nonmetastatic Desmoplastic Medulloblastoma in Children Younger Than 4 Years of Age: A Report of the Children's Oncology Group (ACNS1221).4 岁以下儿童非转移性促结缔组织增生性髓母细胞瘤的 II 期研究：儿童肿瘤学组的报告（ACNS1221）。
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新诊断的髓母细胞瘤患儿的大剂量化疗

High-Dose Chemotherapy in Children with Newly Diagnosed Medulloblastoma.

作者信息

Lafay-Cousin Lucie, Dufour Christelle

机构信息

Section of Pediatric Hematology Oncology and Bone Marrow Transplantation, Alberta Children's Hospital, Calgary, AB T3B 6A8, Canada.

Department of Pediatric and Adolescent Oncology, Gustave Roussy, 96805 Villejuif, France.

出版信息

Cancers (Basel). 2022 Feb 7;14(3):837. doi: 10.3390/cancers14030837.

DOI:10.3390/cancers14030837
PMID:35159104
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8834150/
Abstract

High-dose chemotherapy with stem cell rescue has been used as an adjuvant therapy or as salvage therapy to treat pediatric patients with brain tumors, and to avoid deleterious side effects of radiotherapy in infants and very young children. Here, we present the most recent trials using high-dose chemotherapy regimens for medulloblastoma in children, and we discuss their contribution to improved survival and describe their toxicity profile and limitations.

摘要

大剂量化疗联合干细胞救援已被用作辅助治疗或挽救治疗，用于治疗患有脑肿瘤的儿科患者，并避免放疗对婴儿和非常年幼儿童产生有害副作用。在此，我们介绍了使用高剂量化疗方案治疗儿童髓母细胞瘤的最新试验，并讨论了它们对提高生存率的贡献，描述了它们的毒性特征和局限性。