Ashurov Jalolboy A, Musa Gerald, Kumirova Ella V, Margaryan Sirak N, Livshitz Matvey I, Ozerov Sergei S, Reyes Soto Gervith, Ramirez Manuel De Jesus Encarnacion, Chmutin Gennady E
Neurological Diseases and Neurosurgery, Peoples' Friendship University of Russia, Moscow, RUS.
Neurosurgery, Morozovskaya Children's City Clinical Hospital, Moscow, RUS.
Cureus. 2024 Aug 30;16(8):e68239. doi: 10.7759/cureus.68239. eCollection 2024 Aug.
A three-year-four-month-old boy with primary disseminated medulloblastoma M3 stage and secondary occlusive hydrocephalus underwent an endoscopic triventriculocisternostomy (ETVC) and tumor biopsy, followed by ventriculoperitoneal shunt (VPS) placement due to ETVC failure. The treatment regimen, which included intensive induction chemotherapy, proton beam therapy (PBT), and maintenance chemotherapy, led to significant clinical improvement and a complete radiological response. Four years post-treatment, the child remains in remission, illustrating the effectiveness of a multimodal approach in managing complex cases of medulloblastoma in pediatric patients.
一名三岁零四个月大的男孩,患有原发性播散性髓母细胞瘤M3期和继发性梗阻性脑积水,接受了内镜下三脑室造瘘术(ETVC)和肿瘤活检,随后因ETVC失败而进行了脑室腹腔分流术(VPS)。治疗方案包括强化诱导化疗、质子束治疗(PBT)和维持化疗,带来了显著的临床改善和完全的影像学缓解。治疗后四年,该患儿仍处于缓解期,说明了多模式方法在治疗小儿髓母细胞瘤复杂病例中的有效性。