Saal S D, Parker T S, Gordon B R, Studebaker J, Hudgins L, Ahrens E H, Rubin A L
Am J Med. 1986 Apr;80(4):583-9. doi: 10.1016/0002-9343(86)90811-9.
A new technique called LDL-pheresis was used in patients to lower low-density lipoprotein cholesterol levels. This procedure combines continuous extracorporeal plasma separation with immunoadsorption of low-density lipoprotein on columns containing monospecific antibody to human apolipoprotein B. Six patients underwent a total of 164 procedures without significant side effects or nonspecific protein depletion. Acutely, LDL-pheresis lowered plasma cholesterol levels by removing up to 82 percent of the circulating low-density lipoprotein. Weekly LDL-pheresis combined with a portacaval shunt in a patient with homozygous familial hypercholesterolemia resulted in normalization of plasma cholesterol levels and rapid regression of skin xanthomata. Three of four patients with atherosclerotic coronary artery disease have noted improvement in their angina. LDL-pheresis appears to be a promising new technique capable of safely and efficiently lowering plasma low-density lipoprotein cholesterol levels.
一种名为低密度脂蛋白分离法的新技术被用于患者以降低低密度脂蛋白胆固醇水平。该程序将连续体外血浆分离与低密度脂蛋白在含有针对人载脂蛋白B的单特异性抗体的柱上的免疫吸附相结合。6名患者共接受了164次该程序，未出现明显副作用或非特异性蛋白质消耗。急性情况下，低密度脂蛋白分离法通过去除高达82%的循环低密度脂蛋白来降低血浆胆固醇水平。在一名纯合子家族性高胆固醇血症患者中，每周进行低密度脂蛋白分离法并结合门腔分流术，使血浆胆固醇水平恢复正常，皮肤黄瘤迅速消退。4名患有动脉粥样硬化性冠状动脉疾病的患者中有3名注意到其心绞痛有所改善。低密度脂蛋白分离法似乎是一种有前景的新技术，能够安全有效地降低血浆低密度脂蛋白胆固醇水平。
