Iskandar S S, Zhang J M, Rodriguez E
Am J Pathol. 1986 Apr;123(1):67-72.
C3H/HeN mice produce small amounts of antibody when challenged daily with 4 mg horse spleen apoferritin and fail to develop significant renal histologic and immunohistologic lesions. When the same dose of antigen is given in cationized form, glomerular deposits of both antigen and IgG, often accompanied by C3, are uniformly found in all animals. Thus it appears that cationized antigens can induce the formation of potentially damaging immune complexes in low-antibody-producing individuals that are not ordinarily susceptible to this kind of immune injury.
当每天用4毫克马脾脱铁铁蛋白攻击时，C3H/HeN小鼠产生少量抗体，且未出现明显的肾脏组织学和免疫组织学损伤。当以阳离子化形式给予相同剂量的抗原时，在所有动物中均能一致发现抗原和IgG的肾小球沉积物，且常伴有C3。因此，似乎阳离子化抗原可在通常不易受到这种免疫损伤的低抗体产生个体中诱导形成潜在有害的免疫复合物。
