酒精性患者血清转铁蛋白的碳水化合物组成

Carbohydrate composition of serum transferrin in alcoholic patients.

作者信息

Stibler H, Borg S

出版信息

Alcohol Clin Exp Res. 1986 Jan-Feb;10(1):61-4. doi: 10.1111/j.1530-0277.1986.tb05616.x.

DOI:10.1111/j.1530-0277.1986.tb05616.x

Abstract

Previous studies have shown that sialic acid-deficient isotransferrins appear in serum during chronic alcohol abuse. In this investigation whole serum transferrin from alcoholic patients and healthy controls was isolated by antitransferrin affinity chromatography and the total levels of sialic acid, galactose, N-acetylglucosamine, and mannose were analyzed. The results showed that the concentrations of sialic acid and galactose as well as N-acetylglucosamine were reduced in all of the alcoholics studied. These findings indicate that chronic ethanol misuse exerts a more complex effect on the glycans of transferrin than previously realized.

摘要

先前的研究表明，慢性酒精滥用期间血清中会出现缺乏唾液酸的同种异铁传递蛋白。在本研究中，通过抗转铁蛋白亲和色谱法从酒精性肝病患者和健康对照者中分离出全血清转铁蛋白，并分析了唾液酸、半乳糖、N-乙酰葡糖胺和甘露糖的总水平。结果显示，所有研究的酗酒者体内唾液酸、半乳糖以及N-乙酰葡糖胺的浓度均降低。这些发现表明，长期滥用乙醇对转铁蛋白聚糖的影响比之前认识到的更为复杂。