Ikegami Takako, Nishikawa Hiroki, Goto Masahiro, Matsui Masahiro, Asai Akira, Ushiro Kosuke, Ogura Takeshi, Takeuchi Toshihisa, Nakamura Shiro, Kakimoto Kazuki, Miyazaki Takako, Fukunishi Shinya, Ohama Hideko, Yokohama Keisuke, Yasuoka Hidetaka, Higuchi Kazuhide
The Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, Osaka, Japan.
The Premier Departmental Research of Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, Osaka, Japan.
J Clin Med. 2022 Jan 24;11(3):582. doi: 10.3390/jcm11030582.
We sought to examine the relationship between the SARC-F score and the Controlling Nutritional Status (CONUT) score in patients with gastrointestinal diseases (GDs, = 735, median age = 71 years, and 188 advanced cancer cases). The SARC-F score ≥ 4 (highly suspicious of sarcopenia) was found in 93 cases (12.7%). Mild malnutritional condition was seen in 310 cases (42.2%), moderate in 127 (17.3%) and severe in 27 (3.7%). The median SARC-F scores in categories of normal, mild, moderate and severe malnutritional condition were 0, 0, 1 and 1 (overall < 0.0001). The percentage of SARC-F score ≥ 4 in categories of normal, mild, moderate and severe malnutritional condition were 4.4%, 12.9%, 26.8% and 25.9% (overall < 0.0001). The SARC-F score was an independent factor for both the CONUT score ≥ 2 (mild, moderate or severe malnutrition) and ≥5 (moderate or severe malnutrition). In the receiver operating characteristic (ROC) curve analysis for the CONUT score ≥ 2, C reactive protein (CRP) had the highest area under the ROC (AUC = 0.70), followed by the SARC-F score (AUC = 0.60). In the ROC analysis for the CONUT score ≥ 5, CRP had the highest AUC (AUC = 0.79), followed by the SARC-F score (AUC = 0.63). In conclusion, the SARC-F score in patients with GDs can reflect malnutritional status.
我们试图研究胃肠道疾病（GDs，n = 735，中位年龄 = 71岁，其中188例为晚期癌症病例）患者的SARC - F评分与控制营养状况（CONUT）评分之间的关系。93例（12.7%）患者的SARC - F评分≥4（高度怀疑肌肉减少症）。310例（42.2%）患者存在轻度营养不良状况，127例（17.3%）为中度，27例（3.7%）为重度。正常、轻度、中度和重度营养不良状况分类中的SARC - F评分中位数分别为0、0、1和1（总体P < 0.0001）。正常、轻度、中度和重度营养不良状况分类中SARC - F评分≥4的百分比分别为4.4%、12.9%、26.8%和25.9%（总体P < 0.0001）。SARC - F评分是CONUT评分≥2（轻度、中度或重度营养不良）和≥5（中度或重度营养不良）的独立因素。在针对CONUT评分≥2的受试者工作特征（ROC）曲线分析中，C反应蛋白（CRP）的ROC曲线下面积（AUC）最高（AUC = 0.70），其次是SARC - F评分（AUC = 0.60）。在针对CONUT评分≥5的ROC分析中，CRP的AUC最高（AUC = 0.79），其次是SARC - F评分（AUC = 0.63）。总之，GDs患者的SARC - F评分可反映营养不良状况。
