1996 - 2015年魁北克炎症性肠病患者中心肌梗死患病率上升及中风比例稳定
Increased Prevalence of Myocardial Infarction and Stable Stroke Proportions in Patients with Inflammatory Bowel Diseases in Quebec in 1996-2015.
作者信息
Golovics Petra Anna, Verdon Christine, Wetwittayakhlang Panu, Filliter Christopher, Gonczi Lorant, Hahn Gustavo Drügg, Wild Gary E, Afif Waqqas, Bitton Alain, Bessissow Talat, Brassard Paul, Lakatos Peter L
机构信息
Division of Gastroenterology, McGill University Health Centre, Montreal, QC H3G 1A4, Canada.
Department of Gastroenterology, Hungarian Defence Forces, Medical Centre, H-1062 Budapest, Hungary.
出版信息
J Clin Med. 2022 Jan 28;11(3):686. doi: 10.3390/jcm11030686.
BACKGROUND
Chronic inflammatory diseases are linked to an increased risk of atherothrombotic events, but the risk associated with inflammatory bowel disease (IBD) is controversial. We therefore examined the risk of and risk factors for myocardial infarction (MI) and stroke in IBD patients.
METHODS
We used the public health administrative database from the Province of Quebec, Canada, to identify IBD patients newly diagnosed between 1996 and 2015. The incidence and prevalence of MI and stroke in IBD patients were compared to those for the Canadian population.
RESULTS
A cohort of 35,985 IBD patients was identified. The prevalence but not incidence rates of MI were higher in IBD patients (prevalence: 3.98%; incidence: 0.234) compared to the Canadian rates (prevalence: 2.0%; incidence: 0.220), while the prevalence and incidence rates of stroke were not significantly higher in the IBD patients (prevalence: 2.98%; incidence: 0.122, vs. Canadian rates: prevalence: 2.60%; incidence: 0.297). We identified age, female gender, hyperlipidemia, diabetes, and hypertension ( < 0.001 for each) as significant risk factors associated with MI and stroke in IBD. Exposure to biologics was associated with a higher incidence of MI (IRR: 1.51; 95% CI: 0.82-2.76; = 0.07) in the insured IBD population.
CONCLUSIONS
An increased prevalence but not incidence of MI and no increased risk of stroke were identified in this population-based IBD cohort.
背景
慢性炎症性疾病与动脉粥样硬化血栓形成事件风险增加相关，但炎症性肠病（IBD）相关风险存在争议。因此，我们研究了IBD患者发生心肌梗死（MI）和中风的风险及危险因素。
方法
我们使用加拿大魁北克省的公共卫生管理数据库，确定1996年至2015年间新诊断的IBD患者。将IBD患者中MI和中风的发病率及患病率与加拿大人群进行比较。
结果
共确定了35985例IBD患者队列。与加拿大人群相比，IBD患者MI的患病率较高（患病率：3.98%；发病率：0.234），但发病率无差异（加拿大人群患病率：2.0%；发病率：0.220），而IBD患者中风的患病率和发病率均无显著升高（患病率：2.98%；发病率：0.122，加拿大人群患病率：2.60%；发病率：0.297）。我们确定年龄、女性、高脂血症、糖尿病和高血压（每项<0.001）为IBD患者发生MI和中风的显著危险因素。在参保的IBD人群中，使用生物制剂与MI的较高发病率相关（发病率比值比：1.51；95%置信区间：0.82 - 2.76；P = 0.07）。
结论
在这个基于人群的IBD队列中，MI的患病率升高但发病率未升高，中风风险也未增加。
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