Dion Ludivine, Santin Gaëlle, Nyangoh Timoh Krystel, Boudjema Karim, Jacquot Thierry Louise, Gauthier Tristan, Carbonnel Marie, Ayoubi Jean Marc, Kerbaul François, Lavoue Vincent
Department of Gynecology, Hôpital Sud, Rennes University Hospital, CEDEX 9, 35200 Rennes, France.
UMR_S 1085, IRSET-INSERM, 35000 Rennes, France.
J Clin Med. 2022 Jan 29;11(3):730. doi: 10.3390/jcm11030730.
Uterus transplantation is a new possibility for women suffering from absolute uterine infertility to become pregnant and have children. In the case of a deceased donor, a list of exclusion criteria is defined to ensure the high quality of the uterus graft. This study evaluates the number of potentially available uterus grafts based on the pre-defined exclusion criteria in a national deceased donor multi-organ donation program in France. We analyzed the data reported in the CRISTAL database regarding all women aged 18 to 60 on whom organ procurement was performed between 2014 and 2019. Potential deceased women donors were classified into three categories: very ideal donor, ideal donor, and expanded criteria donor. Between 2014 and 2019, 4544 women underwent organ procurement. Using the very ideal donor, ideal donor, and expanded criteria donor classification, we found that, respectively, only 124, 264, and 936 donors were potentially eligible for UTx. This represents 2.8 per million people (PMP) very ideal donors, 3.8 PMP ideal donors, 8.6 PMP expanded criteria donors (ECDs). The restricted number of grafts requires a complementary strategy of living and deceased donors to meet the demand of all women with AUI.
子宫移植为患有绝对子宫性不孕的女性提供了怀孕生子的新可能。对于已故捐赠者，需定义一系列排除标准以确保子宫移植物的高质量。本研究基于法国全国已故捐赠者多器官捐赠项目中预先定义的排除标准，评估了潜在可用子宫移植物的数量。我们分析了CRISTAL数据库中报告的2014年至2019年间所有接受器官获取的18至60岁女性的数据。潜在的已故女性捐赠者被分为三类：非常理想的捐赠者、理想的捐赠者和扩展标准捐赠者。2014年至2019年间，4544名女性接受了器官获取。使用非常理想的捐赠者、理想的捐赠者和扩展标准捐赠者分类方法，我们发现分别只有124名、264名和936名捐赠者可能符合子宫移植的条件。这分别代表每百万人口中有2.8名非常理想的捐赠者、3.8名理想的捐赠者、8.6名扩展标准捐赠者（ECD）。移植物数量有限，需要活体和已故捐赠者的补充策略来满足所有绝对子宫性不孕女性的需求。
