女性皮肤黑色素瘤
Cutaneous melanoma in women.
作者信息
Roh Mi Ryung, Eliades Philip, Gupta Sameer, Grant-Kels Jane M, Tsao Hensin
机构信息
Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Department of Dermatology, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.
出版信息
Int J Womens Dermatol. 2017 Feb 16;3(1 Suppl):S11-S15. doi: 10.1016/j.ijwd.2017.02.003. eCollection 2017 Mar.
BACKGROUND
Gender disparity in melanoma outcome is consistently observed, suggesting that gender is as an important prognostic factor. However, the source of this gender disparity in melanoma remains unclear.
OBJECTIVE
This article reviews advances in our understanding of gender differences in melanoma and how such differences may contribute to outcomes.
METHODS
A broad literature search was conducted using the PubMed database, with search terms such as 'gender differences in melanoma' and 'sex differences in melanoma.' Additional articles were identified from cited references.
RESULTS
Herein, we address the gender-linked physiologic differences in skin and melanoma. We discuss the influence of estrogen on a woman's risk for melanoma and melanoma outcomes with regard to pregnancy, oral contraceptives, hormone replacement therapy, and UV tanning.
CONCLUSIONS
The published findings on gender disparities in melanoma have yielded many advances in our understanding of this disease. Biological, environmental, and behavioral factors may explain the observed gender difference in melanoma incidence and outcome. Further research will enable us to learn more about melanoma pathogenesis, with the goal of offering better treatments and preventative advice to our patients.
背景
黑色素瘤预后的性别差异一直存在，这表明性别是一个重要的预后因素。然而，黑色素瘤中这种性别差异的根源仍不清楚。
目的
本文综述了我们对黑色素瘤性别差异的理解进展，以及这些差异如何影响预后。
方法
使用PubMed数据库进行广泛的文献检索，检索词包括“黑色素瘤的性别差异”和“黑色素瘤的性别差异”。从引用文献中识别出其他文章。
结果
在此，我们探讨了皮肤和黑色素瘤中与性别相关的生理差异。我们讨论了雌激素对女性患黑色素瘤风险的影响，以及在妊娠、口服避孕药、激素替代疗法和紫外线晒黑方面黑色素瘤的预后。
结论
关于黑色素瘤性别差异的已发表研究结果使我们对这种疾病的理解有了许多进展。生物学、环境和行为因素可能解释了观察到的黑色素瘤发病率和预后的性别差异。进一步的研究将使我们能够更多地了解黑色素瘤的发病机制，目标是为我们的患者提供更好的治疗和预防建议。
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