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作为生物医学工具的聚电解质多层胶囊

Polyelectrolyte Multilayered Capsules as Biomedical Tools.

作者信息

Mateos-Maroto Ana, Fernández-Peña Laura, Abelenda-Núñez Irene, Ortega Francisco, Rubio Ramón G, Guzmán Eduardo

机构信息

Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.

Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.

出版信息

Polymers (Basel). 2022 Jan 25;14(3):479. doi: 10.3390/polym14030479.

DOI:10.3390/polym14030479
PMID:35160468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8838751/
Abstract

Polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method have become powerful tools for different biomedical applications, which include drug delivery, theranosis or biosensing. However, the exploitation of PEMUCs in the biomedical field requires a deep understanding of the most fundamental bases underlying their assembly processes, and the control of their properties to fabricate novel materials with optimized ability for specific targeting and therapeutic capacity. This review presents an updated perspective on the multiple avenues opened for the application of PEMUCs to the biomedical field, aiming to highlight some of the most important advantages offered by the LbL method for the fabrication of platforms for their use in the detection and treatment of different diseases.

摘要

采用层层（LbL）法制备的聚电解质多层胶囊（PEMUCs）已成为用于不同生物医学应用的强大工具，这些应用包括药物递送、诊疗或生物传感。然而，在生物医学领域利用PEMUCs需要深入了解其组装过程的最基本原理，并控制其性质以制造具有优化的特定靶向能力和治疗能力的新型材料。本综述提供了关于PEMUCs在生物医学领域应用所开辟的多种途径的最新观点，旨在突出层层法在制造用于检测和治疗不同疾病的平台方面提供的一些最重要优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/ebb43f9fcdca/polymers-14-00479-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/951829eedcfd/polymers-14-00479-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/36c668c2046c/polymers-14-00479-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/8f1c434a6915/polymers-14-00479-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/f4a9203ab416/polymers-14-00479-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/17b059f122ed/polymers-14-00479-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/b1fccd36dbec/polymers-14-00479-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/776fa9e51e61/polymers-14-00479-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/ebb43f9fcdca/polymers-14-00479-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/cb3699c9ef1f/polymers-14-00479-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/0cf3a242478e/polymers-14-00479-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/a2f1ca99166a/polymers-14-00479-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/19dec8039f51/polymers-14-00479-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/951829eedcfd/polymers-14-00479-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/36c668c2046c/polymers-14-00479-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/8f1c434a6915/polymers-14-00479-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/f4a9203ab416/polymers-14-00479-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/17b059f122ed/polymers-14-00479-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/b1fccd36dbec/polymers-14-00479-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/776fa9e51e61/polymers-14-00479-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c01/8838751/ebb43f9fcdca/polymers-14-00479-g012.jpg

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本文引用的文献

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2
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ACS Appl Bio Mater. 2019 Dec 16;2(12):5512-5527. doi: 10.1021/acsabm.9b00703. Epub 2019 Nov 11.
3
Multilayer dextran derivative based capsules fighting bacteria resistant to Antibiotic: Case of Kanamycin-Resistant Escherichia coli.
基于壳聚糖的层层组装可食用涂层在保存柑橘果实生物活性化合物和有机酸方面的应用
Food Chem X. 2023 Jan 11;17:100575. doi: 10.1016/j.fochx.2023.100575. eCollection 2023 Mar 30.
基于多层葡聚糖衍生物的胶囊对抗抗生素耐药细菌：以耐卡那霉素大肠杆菌为例。
Int J Biol Macromol. 2022 Mar 1;200:242-246. doi: 10.1016/j.ijbiomac.2021.12.123. Epub 2021 Dec 27.
4
There is still plenty of room for layer-by-layer assembly for constructing nanoarchitectonics-based materials and devices.在基于纳米构筑的材料和器件的逐层组装方面，仍然有很大的空间。
Phys Chem Chem Phys. 2022 Feb 16;24(7):4097-4115. doi: 10.1039/d1cp04669a.
5
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Nanomaterials (Basel). 2021 Nov 13;11(11):3055. doi: 10.3390/nano11113055.
6
Mimicking natural strategies to create multi-environment enzymatic reactors: From natural cell compartments to artificial polyelectrolyte reactors.模仿自然策略构建多环境酶反应器：从天然细胞区室到人工聚电解质反应器。
Biotechnol Adv. 2022 Jan-Feb;54:107798. doi: 10.1016/j.biotechadv.2021.107798. Epub 2021 Jul 12.
7
New sight at the organization of layers of multilayer polyelectrolyte microcapsules.多层聚电解质微胶囊层状结构的新观察。
Sci Rep. 2021 Jul 7;11(1):14040. doi: 10.1038/s41598-021-93565-2.
8
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Mater Sci Eng C Mater Biol Appl. 2021 Jul;126:112161. doi: 10.1016/j.msec.2021.112161. Epub 2021 May 1.
9
Optimally designed theranostic system based folic acids and chitosan as a promising mucoadhesive delivery system for encapsulating curcumin LbL nano-template against invasiveness of breast cancer.基于叶酸和壳聚糖的优化设计治疗诊断系统作为一种有前途的黏附性递送系统，用于封装姜黄素 LbL 纳米模板以对抗乳腺癌的侵袭性。
Int J Biol Macromol. 2021 Jul 1;182:1981-1993. doi: 10.1016/j.ijbiomac.2021.05.149. Epub 2021 May 28.
10
Calcium Carbonate Core-Shell Particles for Incorporation of Ac and Their Application in Local α-Radionuclide Therapy.碳酸钙核壳粒子的 Ac 掺入及其在局部α放射性核素治疗中的应用。
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