Mateos-Maroto Ana, Fernández-Peña Laura, Abelenda-Núñez Irene, Ortega Francisco, Rubio Ramón G, Guzmán Eduardo
Departamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, Spain.
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Polymers (Basel). 2022 Jan 25;14(3):479. doi: 10.3390/polym14030479.
Polyelectrolyte multilayered capsules (PEMUCs) obtained using the Layer-by-Layer (LbL) method have become powerful tools for different biomedical applications, which include drug delivery, theranosis or biosensing. However, the exploitation of PEMUCs in the biomedical field requires a deep understanding of the most fundamental bases underlying their assembly processes, and the control of their properties to fabricate novel materials with optimized ability for specific targeting and therapeutic capacity. This review presents an updated perspective on the multiple avenues opened for the application of PEMUCs to the biomedical field, aiming to highlight some of the most important advantages offered by the LbL method for the fabrication of platforms for their use in the detection and treatment of different diseases.
采用层层(LbL)法制备的聚电解质多层胶囊(PEMUCs)已成为用于不同生物医学应用的强大工具,这些应用包括药物递送、诊疗或生物传感。然而,在生物医学领域利用PEMUCs需要深入了解其组装过程的最基本原理,并控制其性质以制造具有优化的特定靶向能力和治疗能力的新型材料。本综述提供了关于PEMUCs在生物医学领域应用所开辟的多种途径的最新观点,旨在突出层层法在制造用于检测和治疗不同疾病的平台方面提供的一些最重要优势。