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双能X线吸收法评估支持的羟基磷灰石新视野——一项初步研究

New Horizons for Hydroxyapatite Supported by DXA Assessment-A Preliminary Study.

作者信息

Litak Jakub, Grochowski Cezary, Rysak Andrzej, Mazurek Marek, Blicharski Tomasz, Kamieniak Piotr, Wolszczak Piotr, Rahnama-Hezavah Mansur, Litak Grzegorz

机构信息

Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland.

Department of Automation, Faculty of Mechanical Engineering, Lublin University of Technology, Nadbystrzycka 36, 20-618 Lublin, Poland.

出版信息

Materials (Basel). 2022 Jan 26;15(3):942. doi: 10.3390/ma15030942.

Abstract

Dual Energy X-ray Absorptiometry (DXA) is a tool that allows the assessment of bone density. It was first presented by Cameron and Sorenson in 1963 and was approved by the Food and Drug Administration. Misplacing the femoral neck box, placing a trochanteric line below the midland and improper placement of boundary lines are the most common errors made during a DXA diagnostic test made by auto analysis. Hydroxyapatite is the most important inorganic component of teeth and bone tissue. It is estimated to constitute up to 70% of human bone weight and up to 50% of its volume. Calcium phosphate comes in many forms; however, studies have shown that only tricalcium phosphate and hydroxyapatite have the characteristics that allow their use as bone-substituted materials. The purpose of this study is aimed at analyzing the results of hip densitometry and hydorxyapatite distribution in order to better assess the structure and mineral density of the femoral neck. However, a detailed analysis of the individual density curves shows some qualitative differences that may be important in assessing bone strength in the area under study. To draw more specific conclusions on the therapy applied for individual patients, we need to determine the correct orientation of the bone from the resulting density and document the trends in the density distribution change. The average results presented with the DXA method are insufficient.

摘要

双能X线吸收法(DXA)是一种用于评估骨密度的工具。它于1963年由卡梅隆和索伦森首次提出,并获得了美国食品药品监督管理局的批准。股骨颈框放置错误、粗隆线置于中部下方以及边界线放置不当是自动分析进行DXA诊断测试时最常见的错误。羟基磷灰石是牙齿和骨组织中最重要的无机成分。据估计,它占人体骨骼重量的70%,占其体积的50%。磷酸钙有多种形式;然而,研究表明,只有磷酸三钙和羟基磷灰石具有可用作骨替代材料的特性。本研究的目的是分析髋部骨密度测定结果和羟基磷灰石分布,以便更好地评估股骨颈的结构和矿物质密度。然而,对个体密度曲线的详细分析显示出一些定性差异,这些差异在评估研究区域的骨强度方面可能很重要。为了对个体患者应用的治疗得出更具体的结论,我们需要根据所得密度确定骨骼的正确方向,并记录密度分布变化的趋势。DXA方法给出的平均结果是不够的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a702/8839981/d339d3f9d687/materials-15-00942-g001.jpg

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