Gao Minhao, Gao Weiyang, Papadimitriou J M, Zhang Changqing, Gao Junjie, Zheng Minghao
1Centre for Orthopaedic Research, Faculty of Health and Medical Sciences, The University of Western Australia, Nedlands, WA 6009 Australia.
2Perron Institute for Neurological and Translational Science, Nedlands, WA 6009 Australia.
Bone Res. 2018 Dec 7;6:36. doi: 10.1038/s41413-018-0039-2. eCollection 2018.
Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells. Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury.
外泌体是一组异质性的细胞来源膜性结构，介导细胞间的相互作用。最近的研究揭示了外泌体与骨稳态之间的密切关系。有研究表明，骨细胞可自发分泌包含蛋白质、脂质和核酸的外泌体，进而调节破骨细胞生成和成骨作用。然而，外泌体在骨稳态中的调控活动网络及其在骨损伤中的治疗潜力仍 largely unknown。本综述将详细讨论外泌体的特征、外泌体在骨稳态中的调控活动以及外泌体在骨损伤中的临床潜力。
原文中“largely unknown”直译为“很大程度上未知”，在译文中为保持中文表达习惯，可根据语境灵活调整表述，这里保留英文未译，因为不太明确“largely”具体想表达的准确意思，若要更准确翻译需结合更多上下文信息。
