Mitchell G H, Hadley T J, McGinniss M H, Klotz F W, Miller L H
Blood. 1986 May;67(5):1519-21.
Plasmodium falciparum malaria parasites with different capabilities of invading sialic acid-deficient erythrocytes were identified. Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated and Tn erythrocytes twice as efficiently as Thai-2 parasites cultured in normal erythrocytes and seven to ten times more efficiently than a cloned line of Camp parasites cultured in normal erythrocytes. All three parasite lines required sialic acid for optimal invasion, but Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated erythrocytes with 45% efficiency whereas Camp parasites invaded neuraminidase-treated erythrocytes with less than 10% efficiency. P falciparum malaria parasites probably possess two receptors: one that binds to a sialic acid-dependent ligand and another that binds to a sialic acid-independent ligand. Parasites may differ in the quantity or affinity of their receptors for the sialic acid-independent ligand.
已鉴定出具有不同侵袭缺乏唾液酸红细胞能力的恶性疟原虫。在Tn红细胞中培养的泰国-2疟原虫侵入经神经氨酸酶处理的红细胞和Tn红细胞的效率是在正常红细胞中培养的泰国-2疟原虫的两倍，是在正常红细胞中培养的克隆的Camp疟原虫系的7至10倍。所有这三种疟原虫系都需要唾液酸才能实现最佳侵袭，但在Tn红细胞中培养的泰国-2疟原虫侵入经神经氨酸酶处理的红细胞的效率为45%，而Camp疟原虫侵入经神经氨酸酶处理的红细胞的效率低于10%。恶性疟原虫可能拥有两种受体：一种与唾液酸依赖性配体结合，另一种与唾液酸非依赖性配体结合。疟原虫对唾液酸非依赖性配体的受体数量或亲和力可能有所不同。
