Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
PhD Program in Drug Discovery and Development, University of Salerno (SA), 84081 Fisciano, Italy.
Int J Mol Sci. 2022 Jan 24;23(3):1280. doi: 10.3390/ijms23031280.
At present, the use of benzimidazole drugs in veterinary medicine is strongly limited by both pharmacokinetics and formulative issues. In this research, the possibility of applying an innovative semi-solid extrusion 3D printing process in a co-axial configuration was speculated, with the aim of producing a new gastro-retentive dosage form loaded with ricobendazole. To obtain the drug delivery system (DDS), the ionotropic gelation of alginate in combination with a divalent cation during the extrusion was exploited. Two feeds were optimized in accordance with the printing requirements and the drug chemical properties: the crosslinking ink, i.e., a water ethanol mixture containing CaCl at two different ratios 0.05 M and 0.1 M, hydroxyethyl cellulose 2% /, Tween 85 0.1% / and Ricobendazole 5% /; and alginate ink, i.e., a sodium alginate solution at 6% /. The characterization of the dried DDS obtained from the extrusion of gels containing different amounts of calcium chloride showed a limited effect on the ink extrudability of the crosslinking agent, which on the contrary strongly influenced the final properties of the DDS, with a difference in the polymeric matrix toughness and resulting effects on floating time and drug release.
目前，苯并咪唑类药物在兽医学中的应用受到药代动力学和制剂问题的强烈限制。在这项研究中，推测可以应用创新的半固态挤出 3D 打印工艺在共轴配置中，目的是生产一种新的载有 ricobendazole 的胃滞留剂型。为了获得药物递送系统（DDS），利用海藻酸盐在挤出过程中与二价阳离子的离子凝胶化。根据打印要求和药物化学性质优化了两种进料：交联墨水，即含有 CaCl 的水乙醇混合物，浓度分别为 0.05 M 和 0.1 M，2%羟乙基纤维素/，0.1%吐温 85/和 5% Ricobendazole/；和海藻酸盐墨水，即 6%的海藻酸钠溶液。对含有不同浓度氯化钙的凝胶挤出得到的干燥 DDS 的特性进行了研究，结果表明交联剂的墨水可挤出性对其影响有限，而交联剂对 DDS 的最终性能有很大影响，聚合物基质的韧性不同，对漂浮时间和药物释放的影响也不同。
