Department of Rural and Biosystems Engineering, College of Agriculture and Life Sciences, Chonnam National University, 77 Yongbong-Ro, Gwangju, 61186, Korea.
Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Pohang, Kyungbuk, 37673, Korea.
Signal Transduct Target Ther. 2021 May 14;6(1):177. doi: 10.1038/s41392-021-00566-8.
Rapid development of vaccines and therapeutics is necessary to tackle the emergence of new pathogens and infectious diseases. To speed up the drug discovery process, the conventional development pipeline can be retooled by introducing advanced in vitro models as alternatives to conventional infectious disease models and by employing advanced technology for the production of medicine and cell/drug delivery systems. In this regard, layer-by-layer construction with a 3D bioprinting system or other technologies provides a beneficial method for developing highly biomimetic and reliable in vitro models for infectious disease research. In addition, the high flexibility and versatility of 3D bioprinting offer advantages in the effective production of vaccines, therapeutics, and relevant delivery systems. Herein, we discuss the potential of 3D bioprinting technologies for the control of infectious diseases. We also suggest that 3D bioprinting in infectious disease research and drug development could be a significant platform technology for the rapid and automated production of tissue/organ models and medicines in the near future.
疫苗和疗法的快速发展对于应对新出现的病原体和传染病至关重要。为了加快药物发现过程，可以通过引入先进的体外模型来替代传统的传染病模型，并采用先进的技术来生产药物和细胞/药物输送系统，对传统的开发管道进行重新配置。在这方面，通过层层构建和 3D 生物打印系统或其他技术，可以为传染病研究开发高度仿生和可靠的体外模型提供有益的方法。此外，3D 生物打印的高灵活性和多功能性在有效生产疫苗、疗法和相关输送系统方面具有优势。本文讨论了 3D 生物打印技术在控制传染病方面的潜力。我们还建议，3D 生物打印在传染病研究和药物开发方面可能成为未来快速和自动化生产组织/器官模型和药物的重要平台技术。
