Pangestuti Ratih, Kim Se-Kwon
Research Center for Oceanography, Indonesian Institute of Sciences (LIPI), Jakarta 14430, Indonesia.
Department of Marine-bio Convergence Science, Pukyong National University, Busan 608-737, Korea.
Mar Drugs. 2017 Mar 9;15(3):67. doi: 10.3390/md15030067.
Non-communicable diseases (NCD) are the leading cause of death and disability worldwide. The four main leading causes of NCD are cardiovascular diseases, cancers, respiratory diseases and diabetes. Recognizing the devastating impact of NCD, novel prevention and treatment strategies are extensively sought. Marine organisms are considered as an important source of bioactive peptides that can exert biological functions to prevent and treatment of NCD. Recent pharmacological investigations reported cardio protective, anticancer, antioxidative, anti-diabetic, and anti-obesity effects of marine-derived bioactive peptides. Moreover, there is available evidence supporting the utilization of marine organisms and its bioactive peptides to alleviate NCD. Marine-derived bioactive peptides are alternative sources for synthetic ingredients that can contribute to a consumer's well-being, as a part of nutraceuticals and functional foods. This contribution focus on the bioactive peptides derived from marine organisms and elaborates its possible prevention and therapeutic roles in NCD.
非传染性疾病(NCD)是全球死亡和残疾的主要原因。非传染性疾病的四大主要病因是心血管疾病、癌症、呼吸系统疾病和糖尿病。认识到非传染性疾病的破坏性影响,人们广泛寻求新的预防和治疗策略。海洋生物被认为是生物活性肽的重要来源,这些生物活性肽可以发挥生物功能来预防和治疗非传染性疾病。最近的药理学研究报道了海洋来源的生物活性肽具有心脏保护、抗癌、抗氧化、抗糖尿病和抗肥胖作用。此外,有证据支持利用海洋生物及其生物活性肽来缓解非传染性疾病。海洋来源的生物活性肽是合成成分的替代来源,作为营养保健品和功能性食品的一部分,有助于消费者的健康。本论文聚焦于海洋生物来源的生物活性肽,并阐述其在非传染性疾病中可能的预防和治疗作用。