University of Medicine, Pharmacy, Science and Technology "George Emil Palade", 540142 Târgu Mureș, Romania.
Department of Neurosurgery, Emergency Clinical County Hospital, 540136 Târgu Mureș, Romania.
Int J Mol Sci. 2022 Jan 27;23(3):1449. doi: 10.3390/ijms23031449.
Brain metastases represent more than 50% of all cerebral tumors encountered in clinical practice. Recently, there has been increased interest in the study of extracellular vesicles, and the knowledge about exosomes is constantly expanding. Exosomes are drivers for organotropic metastatic spread, playing important roles in the brain metastatic process by increasing the permeability of the blood-brain barrier and preparing the premetastatic niche. The promising results of the latest experimental studies raise the possibility of one day using exosomes for liquid biopsies or as drug carriers, contributing to early diagnosis and improving the efficacy of chemotherapy in patients with brain metastases. In this review, we attempted to summarize the latest knowledge about the role of exosomes in the brain metastatic process and future research directions for the use of exosomes in patients suffering from brain metastatic disease.
脑转移瘤占临床实践中遇到的所有脑肿瘤的 50%以上。最近，人们对细胞外囊泡的研究产生了浓厚的兴趣，对外泌体的认识也在不断扩展。外泌体是器官趋向性转移扩散的驱动因素，通过增加血脑屏障的通透性和准备前转移龛，在外泌体在脑转移过程中发挥重要作用。最新实验研究的有希望的结果提出了有朝一日可能使用外泌体进行液体活检或作为药物载体的可能性，有助于早期诊断和提高脑转移患者化疗的疗效。在这篇综述中，我们试图总结外泌体在脑转移过程中的最新知识，以及在脑转移疾病患者中使用外泌体的未来研究方向。
