Tudor Lucija, Podobnik Josip, Nedic Erjavec Gordana, Nikolac Perkovic Matea, Harro Jaanus, Kanarik Margus, Marcinko Darko, Svob Strac Dubravka, Cusek Melita, Kovac Vlatka, Pivac Nela
Rudjer Boskovic Institute, Division of Molecular Medicine, 10000 Zagreb, Croatia.
Department of Psychiatry, Psychiatric Hospital for Children and Youth Zagreb, 10000 Zagreb, Croatia.
Biomolecules. 2025 Apr 9;15(4):554. doi: 10.3390/biom15040554.
Aggression constitutes a significant behavioral issue associated with delinquent behavior, commonly observed in youth diagnosed with conduct disorder (CD) and living in correctional facilities. Catechol-o-methyl-transferase gene variants modify the environmental sensitivity associated with the risk of aggression. This study evaluated the association of rs4680 and rs4818 polymorphisms with aggressive behavior in 341 male adolescents living inside and outside a correctional facility, with or without a diagnosis of CD. Aggression was assessed using the Hare Psychopathy Checklist: Youth Version (PCL-YV), Modified Overt Aggression Scale (MOAS) and Swanson, Nolan and Pelham Questionnaire. rs4680 and rs4818 polymorphisms were genotyped using TaqMan SNP Genotyping Assays. A similar prevalence of the genotypes or haplotypes was found between adolescents with or without CD, suicidal behavior, or detention in correctional facility. In youth with CD, the rs4680 A allele was associated with higher MOAS verbal aggression, aggression toward objects, irritability (subjective and open), and PCL-YV interpersonal domain scores compared with carriers of the rs4680 G allele. rs4818 GC carriers with CD had higher scores on the MOAS subjective irritability than GG heterozygotes. These novel findings revealed the association of lower rs4680 and rs4818 activity alleles with aggression in detained male adolescents with CD.
攻击行为是与犯罪行为相关的一个重要行为问题，常见于被诊断患有品行障碍（CD）且生活在教养机构中的青少年。儿茶酚-O-甲基转移酶基因变异会改变与攻击风险相关的环境敏感性。本研究评估了rs4680和rs4818多态性与341名生活在教养机构内外、有无CD诊断的男性青少年攻击行为之间的关联。使用《哈雷精神病态检查表：青少年版》（PCL-YV）、修订版公开攻击量表（MOAS）以及斯旺森、诺兰和佩勒姆问卷对攻击行为进行评估。使用TaqMan SNP基因分型检测对rs4680和rs4818多态性进行基因分型。在有无CD、自杀行为或被拘留在教养机构的青少年之间，发现基因型或单倍型的患病率相似。在患有CD的青少年中，与rs4680 G等位基因携带者相比，rs4680 A等位基因与更高的MOAS言语攻击、对物体的攻击、易怒（主观和公开）以及PCL-YV人际领域得分相关。患有CD的rs4818 GC携带者在MOAS主观易怒方面的得分高于GG杂合子。这些新发现揭示了rs4680和rs4818低活性等位基因与被拘留的患有CD的男性青少年攻击行为之间的关联。
