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[青少年抑郁症与基因多态性关联的近期研究]

[Recent research on the association between depressive disorder and gene polymorphisms in adolescents].

作者信息

Yao Ke-Ke, Dong Qiang-Li, Ye Lan-Xian

机构信息

Department of Psychiatry, Lanzhou University Second Hospital, Lanzhou 730030, China.

出版信息

Zhongguo Dang Dai Er Ke Za Zhi. 2023 Mar 15;25(3):328-332. doi: 10.7499/j.issn.1008-8830.2208178.

DOI:10.7499/j.issn.1008-8830.2208178
PMID:36946171
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10032068/
Abstract

Biogenetics plays an important role in the pathogenesis of depressive disorder in adolescents. Various genetic polymorphism studies have updated the understanding of adolescent depressive disorder. However, due to the influence of gene-environment interaction and age of puberty, the influence of gene polymorphisms on adolescent depressive disorder is complicated to clarify. Investigating and clarifying the relationship between gene polymorphisms and adolescent depressive disorder will promote the research on the pathogenesis of this disorder and provide a reference for the prevention and treatment of this disorder. This article reviews the genetic polymorphisms related to adolescent depressive disorder.

摘要

生物遗传学在青少年抑郁症的发病机制中起着重要作用。各种基因多态性研究更新了对青少年抑郁症的认识。然而，由于基因 - 环境相互作用和青春期年龄的影响，基因多态性对青少年抑郁症的影响难以阐明。研究并阐明基因多态性与青少年抑郁症之间的关系将促进对该疾病发病机制的研究，并为该疾病的预防和治疗提供参考。本文综述了与青少年抑郁症相关的基因多态性。

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本文引用的文献

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Genes (Basel). 2022 Mar 5;13(3):464. doi: 10.3390/genes13030464.
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A Systematic Review of Candidate Genes for Major Depression.重度抑郁症候选基因的系统评价
Medicina (Kaunas). 2022 Feb 14;58(2):285. doi: 10.3390/medicina58020285.
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Val/Met and Psychopathic Traits in Children and Adolescents: A Systematic Review and New Evidence of a Developmental Trajectory toward Psychopathy.Val/Met 与儿童和青少年的精神病态特征：系统综述及向精神病态发展轨迹的新证据。
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Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: A systematic narrative review.催产素受体基因（OXTR）多态性与儿童和青少年的社会、情感和行为功能：系统叙述性综述。
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