端粒功能障碍与衰老和衰老相关疾病。
Telomere dysfunction in ageing and age-related diseases.
机构信息
IFOM Foundation-FIRC Institute of Molecular Oncology Foundation, Milan, Italy.
Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
出版信息
Nat Cell Biol. 2022 Feb;24(2):135-147. doi: 10.1038/s41556-022-00842-x. Epub 2022 Feb 14.
Abstract
Ageing organisms accumulate senescent cells that are thought to contribute to body dysfunction. Telomere shortening and damage are recognized causes of cellular senescence and ageing. Several human conditions associated with normal ageing are precipitated by accelerated telomere dysfunction. Here, we systematize a large body of evidence and propose a coherent perspective to recognize the broad contribution of telomeric dysfunction to human pathologies.
摘要
衰老生物体会积累衰老细胞，这些细胞被认为会导致身体功能障碍。端粒缩短和损伤被认为是细胞衰老和老化的原因。几种与正常衰老相关的人类疾病是由端粒功能障碍加速引起的。在这里，我们系统地整理了大量的证据，并提出了一个连贯的观点，以认识到端粒功能障碍对人类疾病的广泛贡献。
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