Zhu X L, Li W J, Wang X E, Song W L, Xu L, Zhang L, Feng X H, Lu R F, Shi D, Meng H X
Department of Stomatology, Peking University People's Hospital, Beijing 100044, China.
Department of Periodontology, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2022 Feb 18;54(1):18-22. doi: 10.19723/j.issn.1671-167X.2022.01.004.
To explore the correlation of cytochrome B-245 alpha chain () rs4673 and cholesteryl ester transfer protein () rs12720922 polymorphisms with the susceptibility of gene-ralized aggressive periodontitis (GAgP).
The study was a case-control trial. A total of 372 GAgP patients and 133 periodontally healthy controls were recruited. The rs4673 and rs12720922 polymorphisms were detected by matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS). Logistic regression models were used to analyze the correlation of rs4673 and rs12720922 variants with the susceptibility of GAgP. The interaction between the two gene polymorphisms to the susceptibility of GAgP was analyzed by the likelihood ratio test. The interaction model adopted was the multiplication model.
The mean age of GAgP group and control group was (27.5±5.2) years and (28.8±7.1) years respectively. There was significant difference in age between the two groups ( < 0.05). The gender distribution (male/female) was 152/220 and 53/80 respectively, and there was no significant difference between GAgP group and controls (>0.05). For rs4673, the frequency of CT/TT genotype in the GAgP group was significantly higher than that in the controls [18.0% (66/366) . 10.6% (14/132), < 0.05]. After adjusting age and gender, the individuals with CT/TT genotype had a higher risk of GAgP (=1.86, 95%: 1.01-3.45, < 0.05), compared with CC genotype. There was no statistically significant difference in distributions of the rs12720922 genotypes (GG, AA/AG) between GAgP patients and healthy controls (>0.05). A significant interaction between rs4673 and rs12720922 in the susceptibility to GAgP was observed. The GAgP risk of the individuals with rs4673 CT/TT and rs12720922 GG genotypes was significantly increased (=3.25, 95%: 1.36-7.75, < 0.01), compared with those carrying CC and AA/AG genotypes.
rs4673 CT/TT genotype is associated with GAgP susceptibility. There is a significant interaction between rs4673 CT/TT genotype and rs12720922 GG genotype in the susceptibility of GAgP.
探讨细胞色素B - 245α链（）rs4673和胆固醇酯转运蛋白（）rs12720922基因多态性与广泛侵袭性牙周炎（GAgP）易感性的相关性。
本研究为病例对照试验。共纳入372例GAgP患者和133例牙周健康对照者。采用基质辅助激光解吸电离飞行时间质谱（MALDI - TOF - MS）检测rs4673和rs12720922基因多态性。运用逻辑回归模型分析rs4673和rs12720922基因变异与GAgP易感性的相关性。通过似然比检验分析两种基因多态性对GAgP易感性的相互作用。采用的相互作用模型为乘法模型。
GAgP组和对照组的平均年龄分别为（27.5±5.2）岁和（28.8±7.1）岁。两组年龄差异有统计学意义（<0.05）。性别分布（男/女）分别为152/220和53/80，GAgP组与对照组之间无显著差异（>0.05）。对于rs4673，GAgP组中CT/TT基因型的频率显著高于对照组[18.0%（66/366）. 10.6%（14/132），<0.05]。调整年龄和性别后，与CC基因型相比，CT/TT基因型个体患GAgP的风险更高（=1.86，95%可信区间：1.01 - 3.45，<0.05）。GAgP患者与健康对照者之间rs12720922基因型（GG、AA/AG）的分布无统计学显著差异（>0.05）。观察到rs4673和rs12720922在GAgP易感性方面存在显著相互作用。与携带CC和AA/AG基因型的个体相比，rs4673为CT/TT且rs12720922为GG基因型的个体患GAgP的风险显著增加（=3.25，95%可信区间：1.36 - 7.75，<0.01）。
rs4673 CT/TT基因型与GAgP易感性相关。rs4673 CT/TT基因型与rs12720922 GG基因型在GAgP易感性方面存在显著相互作用。
