Kabir Shadman, Lingappa Nimisha, Mayrovitz Harvey
Osteopathic Medicine, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA.
Medical Education, Nova Southeastern University Dr. Kiran C. Patel College of Allopathic Medicine, Davie, USA.
Cureus. 2022 Jan 12;14(1):e21154. doi: 10.7759/cureus.21154. eCollection 2022 Jan.
Doxorubicin (DOX) is an anthracycline antibiotic used to treat many cancers, including breast cancer, leukemia, and Hodgkin's lymphoma. Positive aspects of DOX use are limited by the cardiomyopathy that it may cause. For this reason, it is crucial to uncover effective treatments against DOX-induced cardiomyopathy (DIC). Oxidative stress plays a pivotal role in DIC, and this understanding has helped guide potential treatments for DIC. The purpose of this study was to review and describe current and emerging treatments for DIC and their potential cardioprotective effects against DIC. The goals were to: (1) provide a single-source report to aid clinicians in exploring different treatment plans that are personalized for their patients and (2) stimulate researchers to consider evaluating promising and emerging treatment modalities. Evolving understanding of DIC pathophysiology remains fundamental in elucidating the course for future medical therapies. The main conclusion of this study was that the use of existing pharmaceutical agents might represent a possible approach towards mitigating DIC with more extensive clinical data. A limitation of all reviewed studies was that none included an experimental model in which DOX was used to treat animals with preexisting cancer. This limitation fails to identify the impacts that cancer may play in DIC pathophysiology and the potential mitigating effects of DIC treatments. Future research should consider this limitation with appropriately revised protocols.
多柔比星（DOX）是一种蒽环类抗生素，用于治疗多种癌症，包括乳腺癌、白血病和霍奇金淋巴瘤。DOX使用的积极方面受到其可能导致的心肌病的限制。因此，找到针对多柔比星诱导的心肌病（DIC）的有效治疗方法至关重要。氧化应激在DIC中起关键作用，这种认识有助于指导DIC的潜在治疗。本研究的目的是回顾和描述DIC的现有和新兴治疗方法及其对DIC的潜在心脏保护作用。目标是：（1）提供一份单一来源的报告，以帮助临床医生探索针对其患者个性化的不同治疗方案，以及（2）激励研究人员考虑评估有前景的新兴治疗方式。对DIC病理生理学不断发展的理解仍然是阐明未来医学治疗方向的基础。本研究的主要结论是，使用现有药物可能是一种减轻DIC的可行方法，且有更广泛的临床数据。所有综述研究的一个局限性是，没有一项研究包括使用DOX治疗已有癌症的动物的实验模型。这一局限性未能确定癌症在DIC病理生理学中可能发挥的作用以及DIC治疗的潜在缓解作用。未来的研究应通过适当修订方案来考虑这一局限性。
